Ultrafiltration and solute kinetics using low sodium peritoneal dialysate

Kidney International
J K LeypoldtT R Shockley

Abstract

Low sodium peritoneal dialysate has been reported to enhance sodium loss and alleviate signs of fluid overload in continuous ambulatory peritoneal dialysis patients. To elucidate the mechanisms involved, we compared ultrafiltration and solute kinetics using low sodium dialysate (LNaD; 105 mEq/liter sodium, 2.5% glucose, 348 mOsm/liter), conventional dialysate with equal osmolality (CD1.5; 132 mEq/liter sodium, 1.5% glucose, 348 mOsm/liter) and conventional dialysate with equal glucose concentration (CD2.5; 132 mEq/liter sodium, 2.5% glucose, 403 mOsm/liter). A 2 liter, six hour exchange of each dialysate was performed on separate days in 10 chronic peritoneal dialysis patients. Transperitoneal solute diffusion was assessed by calculating the permeability-area product (PA) of the peritoneal membrane from the dependence of plasma and dialysate solute concentrations on tie. Net fluid removed using LNaD of 190 +/- 90 (SEM) ml was similar to that using CD2.5 (250 +/- 90 ml) but higher (P < 0.01) than that using CD1.5 (-200 +/- 60 ml). Sodium loss was higher using LNaD (72 +/- 11 mEq, P < 0.01) and CD2.5 (41 +/- 12 mEq, P < 0.05) than using CD1.5 (-18 +/- 8 mEq). Changes in plasma sodium concentration were small during each dwell and...Continue Reading

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Citations

Jun 23, 1999·Journal of Nephrology·G C CancariniR Maiorca
Nov 20, 2002·Seminars in Dialysis·J Passlick-DeetjenH Schilling
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo La MiliaFrancesco Locatelli
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon DaviesBengt Rippe
Aug 14, 2012·Artificial Organs·Magda Galach, Jacek Waniewski
Jul 16, 2004·Kidney International·Watske SmitRaymond T Krediet
Sep 22, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bolesław RutkowskiUNKNOWN Low Sodium Balance Study Group
Apr 20, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peter G Blake
Nov 10, 2000·Advances in Renal Replacement Therapy·R T Krediet
Nov 10, 2000·Advances in Renal Replacement Therapy·R Gokal
Oct 21, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Vasilios VaiosRajiv Agarwal
May 28, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Bolesław RutkowskiUNKNOWN Low Sodium balance Study Group
Nov 18, 2019·Journal of Nephrology·Silvio BorrelliUNKNOWN Research Group of Peritoneal Dialysis of Italian Society of Nephrology

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