Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

Biomaterials Science
Xiaoqiu LiYucai Wang

Abstract

Cancer radiation therapy (RT) is limited by endogenous DNA repair of tumor cells and microenvironmental hypoxia in tumor tissues. Herein, we demonstrated an effective cancer chemo-radiotherapy strategy based on choline phosphate liposomal nanomedicines, which inhibit the intrinsic radioresistance of RT and concomitantly harness the RT-induced hypoxia to produce additional toxicity to overcome post-RT radioresistance. To achieve this strategy, a radiotherapy sensitizer, vorinostat, and a hypoxia-activated banoxantrone dihydrochloride (AQ4N) were simultaneously delivered to a tumor using liposomes composed of an inverted polarity lipid 2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate (DOCPe). The DOCPe liposomes exhibited a longer blood circulation time and enhanced tumor accumulation, compared to their zwitterionic phosphocholine counterpart. The RT was sensitized by vorinostat to kill non-tolerant normoxic tumor cells efficiently. The irradiation aggravated hypoxia-activated AQ4N to further potentiate RT treatment. This chemo-radiotherapy combination showed excellent tumor treatment efficacy and is promising for future clinical translation.

References

Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Dec 21, 2006·Journal of the National Cancer Institute·Maximilian Diehn, Michael F Clarke
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J Chen, Chaitanya S Nirodi
Feb 8, 2008·Nature Reviews. Cancer·Thomas HelledayRicky A Sharma
May 31, 2008·Nature Reviews. Cancer·Michael BaumannRichard Hill
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Jul 23, 2009·Journal of Cellular Biochemistry·Erina VlashiFrank Pajonk
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Jul 14, 2010·Breast Cancer Research : BCR·Gaetano Zafarana, Robert G Bristow
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·J-H LeePaul A Marks
Aug 10, 2010·Cell·Michael R Lieber, Thomas E Wilson
Sep 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erina VlashiFrank Pajonk
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Nov 28, 2012·Nature Reviews. Clinical Oncology·Juliette ThariatJean-Pierre Gérard
May 16, 2014·Nature Reviews. Cancer·Daniele M GilkesDenis Wirtz
Aug 19, 2014·Nature Reviews. Drug Discovery·Katrina J Falkenberg, Ricky W Johnstone
May 27, 2015·Chemical Reviews·Bhushan S PattniVladimir P Torchilin
Jun 25, 2015·Nature Reviews. Cancer·Holly E BarkerKevin J Harrington
Jul 1, 2015·Nature Reviews. Clinical Oncology·Dörthe Schaue, William H McBride
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yvonne LoratClaudia E Rübe
Jun 2, 2016·Nature Reviews. Clinical Oncology·Ricky A SharmaUNKNOWN NCRI CTRad Academia-Pharma Joint Working Group
Jun 6, 2016·Advanced Drug Delivery Reviews·Shawn StapletonMichael Milosevic
Dec 30, 2016·Radiation Oncology Journal·Beom-Ju HongG-One Ahn
Jan 8, 2017·Biomaterials·Leoni A Kunz-SchughartSuman Pokhrel
Feb 16, 2017·Journal of Cellular Physiology·Rana Jahanban-EsfahlanBahman Yousefi
Mar 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yibo LiuJuewen Liu

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Citations

Jan 6, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Yibo LiuJuewen Liu
Aug 17, 2021·Frontiers in Oncology·Yue LiXiao-Feng Li
Jan 8, 2022·Advanced Science·Xiaoxue HouJianfeng Liu

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Methods Mentioned

BETA
X-ray
fluorescence imaging
flow cytometry
Confocal microscopy
Fluorescence
fluorescence microscopy

Software Mentioned

TissueFAXS Viewer
TissueGnostics

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