Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.

M Alejandra TortoriciDavid Veesler


Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.


Oct 1, 1990·Antiviral Research·M N Prichard, C Shipman
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
May 14, 2005·Journal of Structural Biology·Christian SulowayBridget Carragher
Aug 1, 2007·Journal of Applied Crystallography·Airlie J McCoyRandy J Read
Jan 9, 2010·Acta Crystallographica. Section D, Biological Crystallography·Vincent B ChenDavid C Richardson
Feb 4, 2010·Acta Crystallographica. Section D, Biological Crystallography·Wolfgang Kabsch
Apr 13, 2010·Acta Crystallographica. Section D, Biological Crystallography·P EmsleyK Cowtan
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bärbel KaufmannMichael G Rossmann
Apr 5, 2011·Acta Crystallographica. Section D, Biological Crystallography·Garib N MurshudovAlexei A Vagin
Nov 20, 2015·Nature Structural & Molecular Biology·Jon AgirreKevin D Cowtan
Jan 23, 2016·Antiviral Research·Guntur Fibriansah, Shee-Mei Lok
Jan 15, 2017·Microbiology Spectrum·Stylianos BournazosJeffrey V Ravetch
Feb 7, 2017·Nature Methods·Ali PunjaniMarcus A Brubaker
Jul 16, 2017·Protein Science : a Publication of the Protein Society·Thomas D GoddardThomas E Ferrin
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jesper PallesenJason S McLellan
Feb 27, 2018·PLoS Pathogens·Emily N GallichotteAravinda M de Silva
Oct 23, 2018·Structure·Brandon FrenzFrank DiMaio
Jan 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Feng LongMichael G Rossmann
Sep 17, 2019·Advances in Virus Research·M Alejandra Tortorici, David Veesler
Oct 8, 2019·Acta Crystallographica. Section D, Structural Biology·Dorothee LiebschnerPaul D Adams
Oct 9, 2019·Nature Methods·Dimitry Tegunov, Patrick Cramer
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 1, 2020·Nature·Jian ShangFang Li

❮ Previous
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Dec 23, 2020·Journal of Translational Medicine·Leonardo MiscioAttilio Bianchi
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Jan 19, 2021·Nature·Christian GaeblerMichel C Nussenzweig
Jan 5, 2021·Frontiers in Molecular Biosciences·Giuseppina MarianoJulien R C Bergeron
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Nov 11, 2020·Pathogens·Jamal HussenAbdullah I A Al-Mubarak
Jan 22, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Mikaela SmitAlexandra Calmy
Jan 23, 2021·Membranes·Jordana Muñoz-BasagoitiNuria Izquierdo-Useros
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Mar 3, 2021·Cell Reports Medicine·Michael S PiepenbrinkJames J Kobie
Feb 11, 2021·Nature·Zijun WangMichel C Nussenzweig
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Mar 17, 2021·Wiener klinische Wochenschrift·Franz X Heinz, Karin Stiasny
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Mar 12, 2021·Nature·Dami A CollierRavindra K Gupta
Apr 3, 2021·Science·Robby DivineDavid Baker
Apr 24, 2021·Microbial Cell Factories·Norma A Valdez-CruzMauricio A Trujillo-Roldán
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Apr 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Phillip PymmWai-Hong Tham
Apr 28, 2021·EMBO Reports·Teresa R WagnerUlrich Rothbauer
May 1, 2021·The Journal of Physical Chemistry. B·Gennady M Verkhivker, Luisa Di Paola
Apr 22, 2021·MBio·Harini NatarajanMargaret E Ackerman
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Methods Mentioned

enzyme-linked immunosorbent assay
surface plasmon resonance
biolayer interferometry
flow cytometry

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