Ultrarapid clozapine metabolism and CYP2D6 gene duplication in a patient with schizophrenia

Personalized Medicine
Dorgival Caetano, Irina Piatkov

Abstract

An optimal clozapine serum level is required for both optimization of clinical response and minimization of troublesome or some of the life-threatening side effects. Serum levels can be influenced by comedication that can cause phenoconversion. When norclozapine/clozapine serum levels and ratios are consistently and significantly lower/higher than expected and there are no concomitant drugs that could account for these findings, further investigation of the genetic variants of CYP1A2, 2D6 and 3A4 are warranted.

References

Apr 1, 1996·Journal of Clinical Psychopharmacology·M J Byerly, C L DeVane
Apr 1, 1997·Cellular and Molecular Neurobiology·J FangR T Coutts
Jun 1, 1997·Pharmacogenetics·R A McLellanM Ingelman-Sundberg
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·D Taylor
Feb 12, 1998·British Journal of Clinical Pharmacology·B EiermannL Bertilsson
Aug 5, 1998·Journal of Clinical Psychopharmacology·J A CarrilloJ Benítez
Apr 22, 1999·Journal of Clinical Psychopharmacology·C L AlfaroL Ereshefsky
Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T I PriorG B Baker
Jan 11, 2000·Clinical Pharmacokinetics·S Kudo, T Ishizaki
Jul 25, 2000·Journal of Clinical Pharmacy and Therapeutics·N PoolsupT L Knight
Nov 30, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·C MeiselJ Brockmöller
Sep 27, 2005·Journal of Psychiatric Practice·Ahsan Y Khan, Sheldon H Preskorn
Oct 13, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
May 20, 2011·Clinical Pharmacology and Therapeutics·M DobrinasC B Eap
Jan 9, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sanja DragovicJan N M Commandeur
Jul 9, 2013·European Journal of Clinical Pharmacology·Jochem G GregoorEibert R Heerdink
Aug 5, 2014·Therapeutic Drug Monitoring·Fabian CzerwenskyWerner Steimer
Oct 21, 2014·PloS One·Deise C FriedrichMara H Hutz

❮ Previous
Next ❯

Citations

Dec 19, 2020·Drug Development Research·Alberto Ortega-VázquezNancy Monroy-Jaramillo

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

© 2022 Meta ULC. All rights reserved