Ultrasensitive photoelectrochemical immunosensor for the detection of amyloid β-protein based on SnO2 /SnS2 /Ag2 S nanocomposites

Biosensors & Bioelectronics
Yaoguang WangQin Wei

Abstract

An ultrasensitive label-free photoelectrochemical (PEC) immunosensor with high visible-light activity was developed for quantitative detection of amyloid β-protein (Aβ) by cross-linking anti-Aβ antibody onto the Ag2S sensitized SnO2/SnS2 nanocomposites. Specifically, SnO2 with flower-like porous nanostructure was innovatively applied in PEC immunosensor as a basal material. It could form a heterostructure with SnS2, which brought about the sensitization of SnO2 and enhanced the separation of photogenerated electrons and holes. Moreover, Ag2S was in-situ growth on the surface of SnO2/SnS2, which further enhanced the photocurrent response significantly. Therefore, SnO2/SnS2/Ag2S could form stepwise band-edge structure, which benefited the light harvesting and provided a good foundation for sensor construction and detection. Under optimal conditions, the PEC immunosensor was used to detect the content of Aβ and exhibited a wide linear concentration range from 0.5 pg mL-1 to 100 ng mL-1, with low limit of detection (0.17 pg mL-1) and limit of quantification (0.56 pg mL-1). Additionally, the designed PEC immunosensor exhibited good reproducibility, specificity, and stability which may find potential applications in the biosensor, bi...Continue Reading

Citations

Jul 7, 2020·Chemical Society Reviews·Kayoung KimChan Beum Park
Aug 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liwei YangDanny K Y Wong
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinhui FengQin Wei
Jun 9, 2020·Frontiers in Chemistry·Ionel Şerban, Alexandru Enesca
Dec 7, 2021·Frontiers in Bioengineering and Biotechnology·Guangli HeYibiao Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biosensor Development & Applications

Biosensor development and applications describe recent progress in biosensor development and their applications in the field of antibiotics and metabolic engineering. Discover the latest research on biosensor development and applications in this feed.