Ultrasensitive split-type electrochemical sensing platform for sensitive determination of organophosphorus pesticides based on MnO2 nanoflower-electron mediator as a signal transduction system.

Analytical and Bioanalytical Chemistry
Yuanfang SunDianping Tang

Abstract

Organophosphorus pesticides (OPs) are extensively used worldwide as agrochemicals; however, excess use may threaten the health of humans. Thus, it is an urgent need to develop a sensitive method for determination of OPs. Herein, a simple and sensitive split-type electrochemical method was developed by using MnO2 nanoflower-electron mediator as a signal transduction element. The MnO2 nanoflower-electron mediator was synthesized and shows an excellent electrochemical signal attributed to the high specific surface area of MnO2 nanoflower. Meanwhile, the inhibition of OPs on butyrylcholinesterase (BChE) was carried out in the homogeneous system. In the absence of target molecule, a large number of thiocholines (TCh) were yielded from hydrolysis of acetylthiocholine (ATCh) by BChE. The MnO2 nanoflower was cracked, and subsequently, multiple electron mediator molecules were released from the platform after treated with TCh, thus decreasing the electrochemical response. Furthermore, the inhibition of OPs on BChE resulted in the reduced generation of TCh, thus inducing the recovery of electrochemical signal. Under the optimal experimental, dichlorvos can be detected in a wide range of 10-6-10-10 M, with a detection limit of 3 × 10-10 M...Continue Reading

References

Jul 8, 2005·Analytical and Bioanalytical Chemistry·Djenaine De Souza, Sergio A S Machado
Oct 4, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rui SuAimin Yu
Jan 3, 2014·Biochemistry Research International·Vikas DhullVikas Hooda
Oct 30, 2014·Analytical Chemistry·Chengzhou ZhuYuehe Lin
Oct 21, 2016·Archives of Toxicology·Shokoufeh HassaniMohammad Abdollahi

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