Ultrasensitivity in (supra)molecularly organized and crowded environments

Cell Biology International
M A AonS Cortassa

Abstract

The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.

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Citations

Jun 7, 2002·Biophysical Chemistry·Miguel A Aon, Sonia Cortassa
Jun 11, 2004·Annual Review of Biochemistry·Susanne M Rafelski, Julie A Theriot
Apr 3, 2007·Analytical Biochemistry·Scott S Morrison, John F Dawson
Feb 6, 2015·Frontiers in Physiology·Miguel A Aon, Sonia Cortassa
Apr 11, 2003·Planta·Diego F Gómez-CasatiAlberto A Iglesias

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