Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance

Scientific Reports
Xiao-Dong ZhangJianping Xie

Abstract

Radiotherapy is often the most straightforward first line cancer treatment for solid tumors. While it is highly effective against tumors, there is also collateral damage to healthy proximal tissues especially with high doses. The use of radiosensitizers is an effective way to boost the killing efficacy of radiotherapy against the tumor while drastically limiting the received dose and reducing the possible damage to normal tissues. Here, we report the design and application of a good radiosensitizer by using ultrasmall Au(29-43)(SG)(27-37) nanoclusters (<2 nm) with a naturally-occurring peptide (e.g., glutathione or GSH) as the protecting shell. The GSH-coated Au(29-43)(SG)(27-37) nanoclusters can escape the RES absorption, leading to a good tumor uptake (~8.1% ID/g at 24 h post injection). As a result, the as-designed Au nanoclusters led to a strong enhancement for radiotherapy, as well as a negligible damage to normal tissues. After the treatment, the ultrasmall Au(29-43)(SG)(27-37) nanoclusters can be efficiently cleared by the kidney, thereby avoiding potential long-term side-effects caused by the accumulation of gold atoms in the body. Our data suggest that the ultrasmall peptide-protected Au nanoclusters are a promising ra...Continue Reading

References

Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S S Legha, I W Dimery
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·V PinzaniP Balmès
Jun 13, 1998·Anti-cancer Drugs·M S AaproS Hatty
Dec 26, 2001·Chemical Reviews·H Ali, J E van Lier
Aug 30, 2003·Oncogene·Usha Kasid, Anatoly Dritschilo
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
May 5, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·P Wardman
Sep 25, 2007·Nature Biotechnology·Hak Soo ChoiJohn V Frangioni
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·James F HainfeldHenry M Smilowitz
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Valentina CarozziGuido Cavaletti
Apr 16, 2009·Cancer Research·Geoffrey von MaltzahnSangeeta N Bhatia
May 30, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Wan Nordiana RahmanMoshi Geso
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chung Hang J ChoiMark E Davis
Jun 4, 2010·Radiation Research·Devika B ChithraniDavid A Jaffray
Jul 21, 2010·Nanoscale·Rongchao Jin
Nov 3, 2010·International Journal of Nanomedicine·Xiao-Dong ZhangFei-Yue Fan
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Suneil JainDavid G Hirst
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 5, 2011·Angewandte Chemie·Chen ZhouJie Zheng
Oct 7, 2011·International Journal of Nanomedicine·Xiao-Dong ZhangFei-Yue Fan
Feb 23, 2012·Scientific Reports·Stephen J McMahonFred J Currell
Mar 31, 2012·Biomaterials·Xiao-Dong ZhangSai-Jun Fan
Jul 7, 2012·Nanoscale·Karl T ButterworthKevin M Prise
Oct 18, 2012·Cancer Research·Shuaidong HuoXing-Jie Liang
Jul 23, 2013·Advanced Healthcare Materials·Xiao-Dong ZhangJianping Xie
Nov 23, 2013·Chemical Communications : Chem Comm·Zhentao LuoJianping Xie
Dec 10, 2013·Nano Letters·Chor Yong TayDavid Tai Leong
Jan 7, 2014·Journal of the American Chemical Society·Yong YuJianping Xie

❮ Previous
Next ❯

Citations

Mar 26, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Kristof ZarschlerKenneth A Dawson
Jul 8, 2015·ACS Nano·Mengxiao Yu, Jie Zheng
May 4, 2016·The Journal of Organic Chemistry·Antonia I AntoniouConstantinos M Athanassopoulos
Apr 30, 2016·ACS Applied Materials & Interfaces·Jing SunHao Liang
Mar 4, 2017·Scientific Reports·D CassanoV Voliani
Mar 16, 2017·Angewandte Chemie·Luca BoselliKenneth A Dawson
May 10, 2017·Biomaterials Science·Lingshan GongJinbin Liu
May 16, 2017·Advanced Healthcare Materials·Kyunglim PyoDongil Lee
May 30, 2017·ACS Applied Materials & Interfaces·Xiaoyu MuXiao-Dong Zhang
Jun 7, 2017·Chemical Reviews·Indranath Chakraborty, Thalappil Pradeep
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
May 6, 2016·The Analyst·Xiao-Rong SongJianping Xie
Jun 7, 2018·Nanoscale·Xi KangManzhou Zhu
Aug 18, 2018·Advanced Materials·Qiaofeng YaoJianping Xie
Aug 30, 2018·Advanced Materials·Jiani XieYuliang Zhao
Nov 15, 2018·Nanomedicine·Sébastien PenninckxStéphane Lucas
Jan 14, 2018·Nature Communications·Yunlong ZhouNicholas A Kotov
Jan 24, 2019·Cancers·Hui WangMark De Ridder
Apr 18, 2019·Faraday Discussions·Stefano Cestellos-BlancoPeidong Yang
Jun 15, 2016·Scientific Reports·Alexey VerkhovtsevAndrey V Solov'yov
May 30, 2019·Chemical Communications : Chem Comm·Mohammad AzharuddinHirak K Patra
Jun 19, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Xinyue DouJianping Xie
Jul 17, 2019·Physical Chemistry Chemical Physics : PCCP·Ting Guo
Sep 4, 2019·Nature Nanotechnology·Colleen N LoynachanMolly M Stevens
Nov 30, 2019·The Analyst·Huili LiAjun Wan
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Estelle PorretJean-Luc Coll
May 16, 2020·Electromagnetic Biology and Medicine·Ashwin Kumar Narasimh AnKavitha Arunachalam
May 21, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Manman XieHui Mao
Jul 1, 2016·Journal of Innovative Optical Health Sciences·Xingya JiangJie Zheng
Aug 19, 2018·Scientific Reports·D ChekryginaM Martins
Jan 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing YeXuemei Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
surface plasmon resonance
transmission electron microscopy
dynamic light scattering
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.