Ultrasmall nanoparticles for radiotherapy: AGuIX

Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
F LuxO Tillement

Abstract

Since twenty years, many nanoparticles based on high atomic number elements have been developed as radiosensitizers. The design of these nanoparticles is limited by the classical rules associated with the development of nanoparticles for oncology and by the specific ones associated to radiosensitizers, which aim to increase the effect of the dose in the tumor area and to spare the health tissues. For this application, systemic administration of nanodrugs is possible. This paper will discuss the development of AGuIX nanoparticles and will emphasize on this example the critical points for the development of a nanodrug for this application. AGuIX nanoparticles display hydrodynamic diameters of a few nanometers and are composed of polysiloxane and gadolinium chelates. This particle has been used in many preclinical studies and is evaluated for a further phase I clinical trial. Finally, in addition to its high radiosensitizing potential, AGuIX display MRI functionality and can be used as theranostic nanodrug for personalized medicine.

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Citations

Oct 16, 2016·Macromolecular Bioscience·Peng MiHoracio Cabral
Aug 28, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Maha HafsiBéatrice Cambien

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