Ultrasmall superparamagnetic iron-oxide-enhanced MR imaging of normal bone marrow in rodents: original research original research

Academic Radiology
Gerhard H SimonHeike E Daldrup-Link

Abstract

The objective is to compare three different ultrasmall superparamagnetic iron oxides (USPIOs) for magnetic resonance (MR) imaging of normal bone marrow in rodents. Femoral bone marrow in 18 Sprague-Dawley rats was examined by using MR imaging before and up to 2 and 24 hours postinjection (PI) of 200 mumol of Fe/kg of SHU555C (n = 6), ferumoxtran-10 (n = 6), or ferumoxytol (n = 6), using T1-weighted (50 ms/1.7 ms/60 degrees = repetition time [TR]/echo time [TE]/flip angle) and T2*-weighted (100 ms/15 ms/38 degrees = TR/TE/flip angle) three-dimensional spoiled gradient recalled echo sequences. USPIO-induced bone marrow was evaluated qualitatively and quantified as signal-to-noise ratio (SNR) and change in signal intensity (DeltaSI) values. A mixed-effect model was fitted to the SNR and DeltaSI values, and differences among USPIOs were tested for significance by using F tests. At 2 hours PI, all three USPIOs showed marked positive signal enhancement on T1-weighted images and a corresponding marked signal loss on T2*-weighted images. At 24 hours PI, the T1 effect of all three USPIOs disappeared, whereas T2*-weighted images showed persistent signal loss on SHU555C and ferumoxytol-enhanced MR images, but not ferumoxtran-10-enhanced M...Continue Reading

References

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Citations

Oct 6, 2006·European Radiology·Heike E Daldrup-LinkThomas M Link
Oct 17, 2012·Investigative Radiology·Pippa StoreyVivian S Lee
May 23, 2007·AJR. American Journal of Roentgenology·Lynne S Steinbach
Nov 22, 2005·Trends in Cardiovascular Medicine·Elie R ChemalyRoger J Hajjar
Feb 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christoph HarmsTracy D Farr
Nov 24, 2006·Stroke; a Journal of Cerebral Circulation·Marlène WiartYves Berthezène
Mar 3, 2007·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yuko FukudaNorio Nakao
Sep 6, 2013·Journal of Magnetic Resonance Imaging : JMRI·Andrea ProttiAjay M Shah
Apr 5, 2014·Contrast Media & Molecular Imaging·Adriano BoniAngelo Bifone
Oct 15, 2013·Journal of Magnetic Resonance Imaging : JMRI·Pippa Storey, Arnaldo A Arbini
Feb 9, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Hossein NejadnikHeike Daldrup-Link

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