Ultrasmall superparamagnetic iron oxide nanoparticle uptake as noninvasive marker of aortic wall inflammation on MRI: proof of concept study

The British Journal of Radiology
Sandeep HedgireMukesh G Harisinghani

Abstract

Radiation therapy for cancer can lead to atherosclerosis by inducing inflammatory changes in the vascular wall. It is difficult to quantitatively measure inflammation on CT and MRI studies. The purpose of this study was to assess the use of ferumoxytol, an ultrasmall superparamagnetic iron oxide nanoparticle, as a noninvasive marker of vessel wall inflammation secondary to radiation therapy in pancreatic cancer patients in comparison with healthy volunteers. MRI of upper abdomen (T1, T2, multi echo T2* weighted imaging) was performed on 3 T magnet before and 48 h after intravenous administration of ferumoxytol in pancreatic cancer patients who underwent radiation therapy (n = 8) and in healthy volunteers (n = 8). R2* value was obtained by drawing regions of interest outlining the aortic wall directly on the T2* medic image and subsequently transposed to the R2* image using Amira software (v. 5.3.2, FEI, Bordeaux, France). The change in R2* values was analyzed by student's t-test. The average change in R2* value of the pancreatic cancer patients was determined to be 216.1 ms-1. The average change R2* value of the control patients was determined to be 54.6 ms-1. Thus, pancreatic cancer patients following radiation therapy had a g...Continue Reading

References

Mar 29, 2001·Cardiovascular Radiation Medicine·L F Fajardo
Mar 20, 2010·Journal of the American College of Cardiology·Martin HallePer Tornvall
Mar 20, 2010·Journal of the American College of Cardiology·Neal L WeintraubDavid Manka
Nov 26, 2013·JACC. Cardiovascular Imaging·Amparo L FigueroaAhmed Tawakol
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karen GabrielsSylvia Heeneman
Feb 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jason L GagliaRalph Weissleder
Feb 19, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shreyas S VasanawalaMustafa R Bashir
Apr 30, 2016·European Heart Journal·Philip Joseph, Ahmed Tawakol
Apr 25, 2017·Kidney International·Gerda B TothEdward A Neuwelt
May 17, 2017·Advanced Drug Delivery Reviews·Amr AlaargWillem J M Mulder

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Citations

Aug 6, 2019·Abdominal Radiology·Hamed KordbachehMukesh G Harisinghani
Jan 12, 2021·Advanced Drug Delivery Reviews·Jun ChenHo-Wook Jun
Apr 8, 2021·Current Cardiovascular Imaging Reports·Yi LuKim-Lien Nguyen

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