Ultrasmall, well-dispersed, hollow siliceous spheres with enhanced endocytosis properties

Small
Jie ZhuChengzhong Yu

Abstract

The synthesis of ultrasmall, well-dispersed, hollow siliceous spheres (HSSs) by using a block copolymer as the template and tetraethoxysilane as a silica source under acidic conditions is reported. After removing the surfactant core of as-synthesized, spherical, silica-coated block-copolymer micelles, HSSs with a uniform particle size of 24.7 nm, a cavity diameter of 11.7 nm, and a wall thickness of 6.5 nm are obtained. It is shown that by surface functionalization of HSSs with methyl groups during synthesis, HSSs can be further dispersed in solvents such as water or ethanol to form a stable sol. Moreover, the hollow cavities are accessible for further loading of functional components. In addition, it is demonstrated that HSSs possess superior endocytosis properties for HeLa cells compared to those of conventional mesoporous silica nanoparticles. A feasible and designable strategy for synthesizing novel well-dispersed hollow structures with ultrasmall diameters instead of conventional ordered mesostructures is provided. It is expected that HSSs may find broad applications in bionanotechnology, such as drug carriers, cell imaging, and targeted therapy.

References

Jun 12, 2003·Journal of the American Chemical Society·Xiao-xiao HeJun Li
Oct 14, 2004·Journal of the American Chemical Society·Daniela R RaduVictor S-Y Lin
Apr 6, 2006·Journal of the American Chemical Society·Xingmao Jiang, C Jeffrey Brinker
May 11, 2006·Journal of the American Chemical Society·Qisheng HuoErica Fang
Nov 16, 2006·Journal of the American Chemical Society·Igor SlowingVictor S-Y Lin
Apr 19, 2007·Annual Review of Biomedical Engineering·Shuming NieJonathan W Simons
Jun 26, 2007·Journal of the American Chemical Society·Igor I SlowingVictor S-Y Lin
Jun 28, 2007·Journal of the American Chemical Society·Jiawei TangChengzhong Yu
Aug 2, 2007·Chemical Communications : Chem Comm·Brian G TrewynVictor S-Y Lin
Nov 3, 2007·Nano Letters·Helen VallhovAlfonso E Garcia-Bennett
Dec 22, 2007·Biomaterials·Jason E FullerRobert S Langer
Jul 26, 2008·Nature Nanotechnology·François TorneyKan Wang

❮ Previous
Next ❯

Citations

Jul 1, 2011·Chemical Communications : Chem Comm·Si-Han WuChung-Yuan Mou
Feb 4, 2014·Journal of Hazardous Materials·Hongning WangChengzhong Yu
Nov 3, 2012·Therapeutic Delivery·Yuting NiutChengzhong Yu
Sep 28, 2010·Journal of Colloid and Interface Science·Zhen-An QiaoQisheng Huo
Jul 12, 2011·Chemistry, an Asian Journal·Jie ZhuChengzhong Yu
Jul 13, 2012·Advanced Materials·Xiaodan HuangDongyuan Zhao
Apr 3, 2012·Journal of Colloid and Interface Science·Meihua YuChengzhong Yu
Jul 24, 2012·Journal of Colloid and Interface Science·Qingnan MengBai Yang
Dec 19, 2013·Chemical Communications : Chem Comm·Meihua YuChengzhong Yu
Oct 14, 2014·Chemical Society Reviews·Yu ZhangJohn Wang
Aug 16, 2016·Advances in Colloid and Interface Science·David WibowoChun-Xia Zhao
Nov 3, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Wen-Liang GongMing-Qiang Zhu
Jun 4, 2013·Methods and Applications in Fluorescence·Xu-Dong WangOtto S Wolfbeis
Sep 24, 2020·Advanced Materials·Yuxing YanYusuke Yamauchi
Jun 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yan YangQihua Yang
May 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wanliang Yang, Baoshan Li
Jul 15, 2020·Pharmaceutics·Ana Maria CarvalhoHenrique Faneca
Nov 5, 2017·Journal of Photochemistry and Photobiology. B, Biology·Munmun BardhanDulal Senapati
May 11, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Fangli ChiQisheng Huo
Nov 7, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Pei YuanChengzhong Yu
Nov 17, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Tenkai WatanabeKazuyuki Kuroda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.