Ultrasonic characterization of human trabecular bone microstructure

Physics in Medicine and Biology
Mikko HakulinenJukka S Jurvelin

Abstract

New quantitative ultrasound (QUS) techniques involving ultrasound backscattering have been introduced for the assessment of bone quality. QUS parameters are affected by the transducer characteristics, e.g. frequency range, wave and pulse length. Although frequency-dependent backscattering has been studied extensively, understanding of the ultrasound scattering phenomenon in trabecular bone is still limited. In the present study, the relationships between QUS parameters and the microstructure of human trabecular bone were investigated experimentally and by using numerical simulations. Speed of sound (SOS), normalized broadband ultrasound attenuation (nBUA), average attenuation, integrated reflection coefficient (IRC) and broadband ultrasound backscatter (BUB) were measured for 26 human trabecular bone cylinders. Subsequently, a high-resolution microCT system was used to determine the microstructural parameters. Moreover, based on the sample-specific microCT data, a numerical model for ultrasound propagation was developed for the simulation of experimental measurements. Experimentally, significant relationships between the QUS parameters and microstructural parameters were demonstrated. The relationships were dependent on the fre...Continue Reading

References

Sep 11, 1992·Calcified Tissue International·S WallachL V Avioli
Jun 30, 1992·Biochemical and Biophysical Research Communications·A J BaileyP W Thompson
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L D SpotilaD J Prockop
Jan 1, 1990·Journal of Computer Assisted Tomography·J C LotzW C Hayes
Aug 1, 1989·Journal of Biomechanical Engineering·C H Turner
Apr 1, 1984·Engineering in Medicine·C M LangtonR W Porter
Jun 1, 1980·Acta Orthopaedica Scandinavica·T D Brown, A B Ferguson
Jul 1, 1994·Calcified Tissue International·C C GlüerH K Genant
Apr 1, 1993·Annals of Medicine·K I Kivirikko
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C F NjehC M Langton
Apr 18, 1998·Clinical Physiology·S H PrinsC Hassager
Aug 8, 1998·Ultrasound in Medicine & Biology·K A Wear, B S Garra
Oct 31, 1998·Journal of Biomechanics·D L Kopperdahl, T M Keaveny
Dec 30, 1998·Calcified Tissue International·D HansH K Genant
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T HildebrandP Rüegsegger
Jul 22, 1999·Ultrasound in Medicine & Biology·G LuoR S Siffert
Jan 1, 2000·The Journal of the Acoustical Society of America·K A Wear
Jan 1, 1997·Computer Methods in Biomechanics and Biomedical Engineering·TOR Hildebrand, PETER Rüegsegger
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C RouxP Laugier
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P H NicholsonS Boonen
Mar 7, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B K HoffmeisterJ Y Rho
Apr 30, 2002·Ultrasound in Medicine & Biology·Patrick H F Nicholson, Mary L Bouxsein
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Vikas PatelSharmila Majumdar
Oct 1, 2003·Calcified Tissue International·B CortetX Marchandise
Jun 24, 2004·Journal of Biomechanics·Chamith S RajapakseGemunu H Gunaratne
Aug 18, 2004·Ultrasound in Medicine & Biology·Mikko A HakulinenJukka S Jurvelin
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jan H WaarsingHarrie Weinans
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eleftherios P PaschalisAdele L Boskey

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Citations

Mar 30, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H IsakssonJ S Jurvelin
Feb 12, 2009·The Journal of the Acoustical Society of America·G HaïatS Naili
Dec 13, 2012·The Journal of the Acoustical Society of America·Brent K HoffmeisterMark E Sellers
Feb 23, 2012·The Journal of the Acoustical Society of America·Keith A WearSheng L Gibson
Aug 4, 2007·The Journal of the Acoustical Society of America·D D Deligianni, K N Apostolopoulos
Mar 22, 2014·Current Osteoporosis Reports·Kay RaumPascal Laugier
Jun 15, 2007·Ultrasound in Medicine & Biology·O RiekkinenJ Töyräs
Jun 23, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Markus K H MaloJuha Töyräs
Nov 18, 2008·Ultrasound in Medicine & Biology·A S AulaJ S Jurvelin
Mar 25, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Stefanie Dencks, Georg Schmitz
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·B K HoffmeisterS C Kaste
Jul 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Muris MujagićRichard S C Cobbold
Dec 20, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Brent K HoffmeisterMark E Sellers
Jul 16, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Serena J ScottChris J Diederich
Nov 2, 2015·The Journal of the Acoustical Society of America·Brent K HoffmeisterSang-Rok Lee
May 20, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Fontes-PereiraW C A Pereira
Dec 22, 2006·Physics in Medicine and Biology·Xiasheng GuoXiufen Gong
Nov 22, 2007·Physics in Medicine and Biology·O RiekkinenJ S Jurvelin
Oct 5, 2006·Physics in Medicine and Biology·J SierpowskaR Lappalainen
Jul 30, 2015·Journal of Biomedical Optics·Lifeng YangAndreas Mandelis
Mar 3, 2018·The Journal of the Acoustical Society of America·Brent K HoffmeisterJinsong Huang
Feb 6, 2017·The Journal of the Acoustical Society of America·Chibuzor T M EnehJuha Töyräs
Jul 2, 2018·The Journal of the Acoustical Society of America·Brent K HoffmeisterAbel A Diaz
May 16, 2020·Computational and Mathematical Methods in Medicine·Weiying MaoRong Zhang
Jan 31, 2021·The Journal of the Acoustical Society of America·Tsirigotis AthanasiosDeligianni Despoina

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