Ultrasonic nanotherapy of breast cancer using novel ultrasound-responsive alginate-shelled perfluorohexane nanodroplets: In vitro and in vivo evaluation

Materials Science & Engineering. C, Materials for Biological Applications
Fatemeh BaghbaniManijhe Mokhtari-Dizaji

Abstract

Development of a new class of multifunctional ultrasound-responsive smart nanocarriers that combine therapeutic properties with diagnostic imaging has gained great attention in recent years. Here, we describe the results of ultrasonic nanotherapy of breast cancer using novel alginate-stabilized perfluorohexane nanodroplets. Doxorubicin (Dox)-loaded multifunctional nanodroplets (Dox-NDs) were synthesized via nanoemulsion process and evaluated in vitro and in vivo with focus on cytotoxicity, hemolytic activity, biodistribution, biosafety, and antitumor activity. Echogenic property of nanodroplets was confirmed by B-mode ultrasound imaging. Tumor therapy using Dox-NDs combined with sonication (Dox-ND-US) resulted in strong in vivo antitumor activity characterized by tumor regression which could be because of on demand efficient ultrasound-aided drug release from nanodroplets in tumor tissue under the action of ultrasound. Dox concentration in tumor area for Dox-ND-US treated group reached 10.9μg/g after sonication for 4min (28kHz, 0.034W/cm2), which was 5.2-fold higher compared to non-sonicated Dox-NDs group. The cardiotoxicity of Dox-NDs was much lower than that of free Dox and no hemolytic activity was observed for Dox-NDs. Stro...Continue Reading

Citations

Nov 28, 2017·Biophysics Reviews·Lemmuel L Tayo
Feb 28, 2019·Journal of Drug Targeting·Pravin Shende, Sajal Jain
Oct 12, 2018·Current Medicinal Chemistry·João A Oshiro-JúniorMarlus Chorilli
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Dec 10, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Bin LeiHonglai Liu

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