Ultrasonic nebulization of albuterol is no more effective than jet nebulization for the treatment of acute asthma in children

Chest
A K NakanishiBruce K Rubin

Abstract

Nebulizer systems used to generate therapeutic aerosols vary in their ability to deliver medication to the airway. In a recent study in 17 adults with stable asthma, albuterol given using an ultrasonic nebulizer (UN) appeared to produce greater bronchodilatation than the same dose of albuterol given by a jet nebulizer (JN). The purpose of this study was to determine if the UN used in that study would produce a better bronchodilator response in children with acute asthma than the JN system that has been in use at Cardinal Glennon Children's Hospital. Randomized, prospective, unblinded study. An urban university children's hospital emergency department. One hundred thirteen children, aged 7 to 16 years, who presented for treatment of acute moderately severe asthma completed this study. After randomization and exclusion of dropouts, 46 children received albuterol by UN and 67 were treated by JN. Pulmonary function tests (PFTs) by spirometry, pulse oximetry, and symptom score at baseline and at 15 and 30 min following a single prescribed treatment. PFT on entry to the study was the same in both groups (FEV1; p>0.97). The change in FEV1 after therapy (UN+0.22 L vs JN+0.37 L) was significant (p<0.05) and favored JN. There was no diff...Continue Reading

References

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Citations

May 10, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Elke KöhlerJürgen Hühnerbein
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·N Roche, G J Huchon
May 13, 2010·Expert Opinion on Drug Delivery·Leslie Y YeoDavid A V Morton
Jul 25, 2003·Pediatric Clinics of North America·Bruce K Rubin, James B Fink
Mar 27, 1999·Pediatric Pulmonology. Supplement·M Dolovich
Jan 22, 2020·Expert Opinion on Drug Delivery·Arzu Ari, James B Fink
Sep 10, 2021·Pediatric Pulmonology·Alejandro TeperFacundo García Bournissen

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