PMID: 9418305Jan 7, 1998Paper

Ultrasonic separations in analytical biotechnology

Trends in Biotechnology
W Terence Coakley

Abstract

Cells in megahertz-frequency noncavitating ultrasonic standing waves concentrate at submillimetre distances and are, as large clumps, easily removed from suspension in flow or batch systems. An ultrasonic filter for perfusion hybridoma culture is now available. Results from small-volume prototype analytical-scale systems can inform the design of effective filter or batch-clarification systems for a wide range of cell sizes, concentrations and sample volumes. Large increases in the rates of aqueous biphasic separations and of the rates and sensitivities of analytical immunocoated particle-agglutination assays occur in standing waves. Ultrasonic manipulation is briefly compared with immunomagnetic and dielectrophoretic separations.

References

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Citations

May 24, 2011·Biomedical Microdevices·Jong Seob JeongK Kirk Shung
Mar 17, 2004·Biosensors & Bioelectronics·Jeremy J HawkesMartin B McDonnell
Nov 19, 2011·Journal of Laboratory Automation·A Lenshof, T Laurell
Mar 8, 2005·Ultrasound in Medicine & Biology·Despina BazouW Terence Coakley
Aug 6, 2002·Ultrasonics·Martyn HillJeremy J Hawkes
Nov 5, 2003·Ultrasound in Medicine & Biology·Sanjay KhannaW Terence Coakley
Dec 1, 2012·Proceedings. Mathematical, Physical, and Engineering Sciences·Alon GrinenkoBruce W Drinkwater
Jan 18, 2007·The Journal of the Acoustical Society of America·Philip L Marston
Apr 2, 2005·Biotechnology Progress·Yu-Hsiang LeeChing-An Peng
May 9, 2012·Ultrasonics·Mauricio Hoyos, Angélica Castro
Jul 1, 2015·IEEE Transactions on Bio-medical Engineering·Yue WuCasey K Chan
May 1, 2004·Critical Reviews in Microbiology·Kelly A Stevens, Lee-Ann Jaykus
Nov 9, 2000·Journal of Immunoassay·M A SobanskiJ G Hastings
Nov 22, 2007·Lab on a Chip·Nicole Pamme
Mar 17, 2012·Lab on a Chip·Jonas JonssonGreger Thornell
Dec 3, 2003·The Journal of the Acoustical Society of America·Martyn Hill
Oct 24, 2003·Journal of Food Protection·Patrick W Benoit, Darrell W Donahue
Aug 5, 2018·The Journal of the Acoustical Society of America·Thomas J MatulaDino De Raad
Jan 1, 2018·The Journal of the Acoustical Society of America·Philip L Marston
Sep 2, 2010·Journal of Colloid and Interface Science·Mehti KokluAli Beskok

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