PMID: 18210991Jan 24, 2008Paper

Ultrasonic sound as an indicator of acute pain in laboratory mice.

Journal of the American Association for Laboratory Animal Science : JAALAS
Wendy O WilliamsAnd Kathleen M Mott

Abstract

In response to pain, mice may vocalize at frequencies above the range of human hearing (greater than 20 kHz). To determine whether an ultrasonic recording system is a reliable tool for assessing acute pain, we measured audible and ultrasonic vocalization in mice subjected to either nonpainful or potentially painful procedures performed routinely in animal facilities. Data were collected from 109 weanling mice (Mus musculus; B6, 129S6-Stab 5b) scheduled for 2 potentially painful procedures: DNA testing by tail snip and identification by ear notching. The mice each were assigned randomly to 1 of 4 groups: 1) actual tail snip, 2) sham tail snip, 3) actual ear notch, or 4) sham ear notch. Vocalizations during the treatments were recorded with an ultrasonic recorder. Most mice (65%; n = 55) demonstrated no vocal response to the potentially painful procedures. More mice that received actual tail snips produced audible sounds (11 of 29 mice) than did those that underwent sham tail snips (0 of 30 mice). In addition, audible vocalizations occurred more frequently during ear notch procedures (8 of 26 mice) than during sham ear-notch manipulations (2 of 24 mice). For all 20 of the mice that produced ultrasonic vocalizations, these calls w...Continue Reading

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