Ultrasonographic assessment of joint pathology in type 2 diabetes and hyperuricemia: The Fremantle Diabetes Study Phase II

Journal of Diabetes and Its Complications
Helen I KeenTimothy M E Davis

Abstract

The prevalence and consequences (articular and extra-articular) of hyperuricemia in type 2 diabetes, especially when asymptomatic (ASH), are incompletely understood. The aim of this study was to use ultrasonography to assess pathology associated with monosodium urate deposition in the joints of well-characterized hyperuricemic patients with type 2 diabetes. A subset of 101 participants (mean age 70.4 years, 59.8% males, median diabetes duration 14.6 years) with hyperuricemia (fasting serum uric acid ≥0.42 mmol/L) from the community-based observational Fremantle Diabetes Study Phase II were assessed by ultrasound for signs of intra-articular urate deposition and inflammation in 14 joints at increased risk of involvement in patients with gout. Most participants had evidence of crystal deposition comprising aggregates (59.4%), tophi (19.8%) or a double contour sign (27.7%), and 37% had a power Doppler signal indicative of inflammation in at least one joint. There was no difference between the prevalence of these abnormalities in those with ASH (n = 60) versus participants with a history of gout (n = 41; P ≥ 0.15). There was no association between a history of ischemic heart disease (reported by 17.8% of participants) and either an...Continue Reading

Citations

Dec 20, 2018·American Journal of Physiology. Renal Physiology·Yingfeng ShiNa Liu
Sep 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wugang ZhangHaifang Chen
Oct 21, 2020·Critical Reviews in Food Science and Nutrition·Yang YangQing Zhou
Dec 27, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Marwin GutierrezDenise Clavijo-Cornejo

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