Ultrasonographic characterization of an experimental model of liver metastases from colon carcinoma in rats

Radiología
J J Echevarria UragaB Fernández-Ruanova

Abstract

To determine the ultrasonographic characteristics of liver metastases induced in a rat model; to evaluate the usefulness of ultrasonography in the noninvasive evaluation of tumor infiltration. We seeded the livers of 46 WAG/RijCrl rats with CC-531 syngeneic colorectal carcinoma cells by intrasplenic inoculation. At 21, 28, 35, 42, 70 days after tumor seeding, we performed a series of ultrasonographic examinations to evaluate tumor induction in different groups of animals: 37 rats were studied with a 10 MHz linear probe and 9 were studied with a 6-18 MHz multifrequency probe. The following signs were considered indicative of tumor development: intrahepatic nodules, sinuate liver borders, lobe enlargement, and extrahepatic masses. Ultrasonographic findings were verified at autopsy. We determined the number of implants, size (less than 3mm, between 3 and 7 mm, or greater than 7 mm), and lobe location for each technique. Compared to the autopsy results, ultrasonography detected 64% of the animals with disease. All the extrahepatic masses were correctly diagnosed. Metastases were identified in 90% of the rats with lesions greater than 7 mm, in 75% of those with implants between 3 and 7 mm, and in 25% of those with lesions less than ...Continue Reading

References

Dec 1, 1977·AJR. American Journal of Roentgenology·W ScheibleG R Leopold
Dec 1, 1973·Journal of Clinical Ultrasound : JCU·G Melki
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·L KopperK Lapis
Feb 1, 1997·The Surgical Clinics of North America·K W MillikanA Doolas

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