Ultrasonographic features of focal cortical dysplasia and their relevance for epilepsy surgery

Neurosurgical Focus
Kevin AkeretNiklaus Krayenbühl

Abstract

OBJECTIVE Surgery has proven to be the best therapeutic option for drug-refractory cases of focal cortical dysplasia (FCD)-associated epilepsy. Seizure outcome primarily depends on the completeness of resection, rendering the intraoperative FCD identification and delineation particularly important. This study aims to assess the diagnostic yield of intraoperative ultrasound (IOUS) in surgery for FCD-associated drug-refractory epilepsy. METHODS The authors prospectively enrolled 15 consecutive patients with drug-refractory epilepsy who underwent an IOUS-assisted microsurgical resection of a radiologically suspected FCD between January 2013 and July 2016. The findings of IOUS were compared with those of presurgical MRI postprocessing and the sonographic characteristics were analyzed in relation to the histopathological findings. The authors investigated the added value of IOUS in achieving completeness of resection and improving postsurgical seizure outcome. RESULTS The neurosurgeon was able to identify the dysplastic tissue by IOUS in all cases. The visualization of FCD type I was more challenging compared to FCD II and the demarcation of its borders was less clear. Postsurgical MRI showed residual dysplasia in 2 of the 3 patient...Continue Reading

References

Jun 1, 1992·Seizure : the Journal of the British Epilepsy Association·R M Dasheiff
Aug 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·D C TaylorJ A Corsellis
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·P S MischelH V Vinters
Apr 3, 1998·Journal of Neurosurgery·N L DorwardD G Thomas
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
May 29, 2000·Brain : a Journal of Neurology·S M Sisodiya
Jul 24, 2002·Brain : a Journal of Neurology·L TassiR Spreafico
Mar 24, 2004·Neurology·A PalminiH V Vinters
Jul 17, 2004·Journal of Neurosurgery·Aaron A Cohen-GadolDennis D Spencer
Jul 28, 2004·Brain & Development·Gary D Clark
Apr 9, 2005·Epilepsia·Chun Kee ChungKi Joong Kim
May 23, 2006·Brain : a Journal of Neurology·Susanne FauserAndreas Schulze-Bonhage
Oct 3, 2006·Acta Neurochirurgica. Supplement·S Mittal, P M Black
Nov 26, 2010·Lancet Neurology·Ingmar Blümcke, Roberto Spreafico
Jul 22, 2011·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·D MillerU Sure
Sep 7, 2011·Brain : a Journal of Neurology·Jan WagnerHans-Jürgen Huppertz
Feb 14, 2012·Journal of Neurosurgery·Nathan C RowlandEdward F Chang
Mar 20, 2012·Brain : a Journal of Neurology·A James BarkovichWilliam B Dobyns
Apr 23, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Georgia RamantaniThomas Bast
Dec 17, 2014·Epilepsia·Susanne FauserAndreas Schulze-Bonhage
Oct 6, 2015·Epilepsia·Renzo GuerriniIngmar Blumcke
Apr 15, 2017·Epilepsy & Behavior : E&B·Jorge Luis Ramírez-MolinaLaura Tassi
Apr 21, 2017·Current Neurology and Neuroscience Reports·Robert S Fisher
Oct 27, 2017·The New England Journal of Medicine·Ingmar BlumckeUNKNOWN EEBB Consortium

❮ Previous
Next ❯

Citations

Dec 7, 2018·Neurology India·Varindera P Singh
May 11, 2021·Frontiers in Oncology·Andrea CaraiCarlo Efisio Marras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.