Ultrasonography screening for hepatocellular carcinoma in Japanese patients with diabetes mellitus

Journal of Diabetes
Atsushi HiraokaKojiro Michitaka

Abstract

Effective surveillance for hepatocellular carcinoma (HCC) in diabetes mellitus (DM) has not been established. We elucidated the risk factors for HCC in DM patients. From 2000 to 2014, 80 patients diagnosed with HCC for the first time who had concomittant DM but no other etiology of liver disease were enrolled as the DM-HCC group. From 2005 October to 2014, after introduction of the abdominal ultrasonography (US) report database, 2083 DM patients with no viral hepatitis, no known autoimmune hepatic diseases, and/or no evidence of alcohol abuse (>60 g/day) were enrolled as the DM-US group. Findings from the first US screening were evaluated. "Elderly" patients were defined as those aged >65 years. Clinical features of DM-HCC patients were evaluated and compared with those of DM-US patients. In the DM-HCC group (54 men, 26 women), the mean (± SD age was 74.1 ± 8.5 years, and mean HbA1c and fibrosis-4 (FIB-4) index were 7.3 ± 1.3% and 4.50 ± 3.42, respectively. Mean tumor diameter was 5.7 ± 3.5 cm, there were 63/13/2/2 patients classified as Child-Pugh A/B/C/unknown, and 56/24 were single/multiple lesions. In the DM-US group, HCC was detected in three patients (0.14%; 0.3% of those classified as elderly). The mean age and FIB-4 ind...Continue Reading

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Citations

Aug 7, 2019·Molecular and Clinical Oncology·Hiroka YamagoKojiro Michitaka
Jun 2, 2020·European Journal of Gastroenterology & Hepatology·Kazuhiro NousoUNKNOWN RELPEC Study Group in Japan
May 8, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takumi KawaguchiTakuji Torimura
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
Jun 23, 2021·Journal of the Chinese Medical Association : JCMA·Shao-Jung Hsu, Hui-Chun Huang

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