Ultrasonography surveillance improves prognosis of patients with hepatocellular carcinoma

Molecular and Clinical Oncology
Hiroka YamagoKojiro Michitaka

Abstract

To examine the effectiveness of ultrasonography (US) for hepatocellular carcinoma (HCC) surveillance, the prognosis of HCC patients who underwent such screening at an expert medical institution or at general clinics were analyzed, as well as those without US surveillance. From October 2006 to December 2014, 872 patients with naïve HCC were enrolled and divided into the surveillance (S)-group (n=398), who underwent follow-up examinations with US, and the non-S group (n=474). The S-group was further subdivided into patients who underwent follow-up surveillance at Ehime Prefectural Central Hospital, an expert medical institution (SE-group, n=189), and those who received surveillance at general clinics (SG-group, n=209). Prognosis and clinical characteristics were analyzed. In the non-S group, the frequency of patients without viral hepatitis (NBNC-HCC) and Tumor, Node, Metastasis stage was greater. As a result, the median survival time (MST) of the non-S group was reduced, compared with the S group (non-S group, 34.1 vs. S group, 68.2 months; P<0.001). Tumor size was significantly different between the SE- and SG-groups (SE-group, 2.0±1.0 vs. SG-group, 2.5±1.3 cm; P<0.001), whereas tumor number (SE-group: 1.5±1.1 vs. SG-group, 1.7...Continue Reading

References

Jan 24, 2004·Journal of Medical Screening·J-G ChenY-R Zhu
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masatoshi KudoTakashi Matsunaga
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Apr 25, 2006·AJR. American Journal of Roentgenology·Masashi HirookaMorikazu Onji
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Hironori TanakaYasushi Shiratori
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Nov 28, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi MakuuchiYoshio Yamaoka
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Nov 26, 2009·Journal of Gastroenterology and Hepatology·Atsushi HiraokaMorikazu Onji
Mar 23, 2011·Journal of Gastroenterology and Hepatology·Atsushi HiraokaKojiro Michitaka
Dec 14, 2011·The American Journal of Gastroenterology·Shuichiro ShiinaKazuhiko Koike
Mar 1, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amit G SingalJorge A Marrero
Jan 28, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro KokudoMasatoshi Makuuchi
Aug 20, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yohei UrataIsao Sakaida
Dec 10, 2015·Journal of Gastroenterology and Hepatology·Atsushi HiraokaHideki Kawasaki
Jun 25, 2016·Diagnostics·Philippe Kolly, Jean-François Dufour
Oct 28, 2016·World Journal of Gastroenterology : WJG·Miriama SmajerovaBarbora Miklosova
Jun 20, 2017·Liver Cancer·Atsushi HiraokaUNKNOWN Real-Life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics)
Jul 8, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Hidenori ToyodaJunko Tanaka
Dec 24, 2018·Cancer Medicine·Atsushi HiraokaUNKNOWN Real-life Practice Experts for HCC (RELPEC) Study Group, HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in J

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.