PMID: 11334281May 4, 2001Paper

Ultrasound accelerates functional recovery after peripheral nerve damage

Neurosurgery
P D MouradMichel Kliot

Abstract

Axonal injury in the peripheral nervous system is common, and often it is associated with severe long-term personal and societal costs. The objective of this study is to use an animal model to demonstrate that transcutaneous ultrasound can accelerate recovery from an axonotmetic injury. The sciatic nerve of adult male Lewis rats was crushed in the right midthigh to cause complete distal degeneration of axons yet maintain continuity of the nerve. Beginning 3 days after surgery, various transcutaneous ultrasound treatments or sham treatments were applied 3 days per week for 30 days to the crush site of rats that were randomly assigned to two groups. In the preliminary experiments, there were three animals in each ultrasound group and two control animals. In the final experiment, there were 22 animals in the ultrasound group and 20 animals in the control group. Recovery was assessed by use of a toe spread assay to quantify a return to normal foot function in the injured leg. Equipment included a hand-held transducer that emitted continuous-wave ultrasound. The most successful ultrasound protocol had a spatial peak, time-averaged intensity of 0.25 W/cm2 operated at 2.25 MHz for 1 minute per application. Rats subjected to the most s...Continue Reading

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References

Jan 1, 1990·Ultrasound in Medicine & Biology·S R Young, M Dyson
Jan 1, 1990·Ultrasound in Medicine & Biology·C S EnwemekaS Mendosa
Jan 1, 1990·Ultrasound in Medicine & Biology·S R Young, M Dyson
Sep 1, 1996·Annals of Neurology·E C Yuen, W C Mobley
Sep 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K H YangM E Bolander
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Apr 8, 1998·BMJ : British Medical Journal·G R EbenbichlerV Fialka
Apr 14, 1999·Neurosurgery·G A GrantM Kliot

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Citations

Aug 29, 2013·Australasian Physical & Engineering Sciences in Medicine·Fatemeh Zareayan JahromyJalal Izadi Mobarake
Feb 21, 2014·Expert Review of Neurotherapeutics·Abdullah M Al-Shenqiti, Jacqueline A Oldham
May 17, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William W Campbell

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