Ultrasound as a diagnostic tool in detecting active Crohn's disease: a meta-analysis of prospective studies

European Radiology
Jianning DongJieshou Li

Abstract

To evaluate the diagnostic accuracy of ultrasound in assessing active Crohn's disease (CD) in adults. We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library for prospective studies in which ultrasound was performed to evaluate active CD in adults from January 1993 to April 2013. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-) and diagnostic odds ratios (DORs) in a per-patient-based analysis were estimated. Additionally, the area under the receiver-operating characteristic (ROC) curve was calculated to measure the diagnostic accuracy of ultrasound in patients with known or suspected CD. Fifteen studies involving 1,558 patients were included in this meta-analysis. Overall, the pooled sensitivity (0.88) and LR- (0.14) were not heterogeneous, whereas the pooled specificity (0.97, I(2) = 72.9 %) and LR + (15.10, I(2) = 71.8 %) were. The DOR of ultrasound for assessing active CD was 121.70, with significant heterogeneity (I(2) = 63.3 %). A symmetrical summary ROC curve was plotted showing that the area under the curve was 0.94, indicating good diagnostic accuracy. Meta-regression and subgroup analysis showed that the disease location may be a major cause of heterogene...Continue Reading

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Citations

Oct 29, 2015·Journal of Crohn's & Colitis·Zbigniew SerafinMaria Klopocka
Nov 9, 2016·MMW Fortschritte der Medizin·Torsten Kucharzik
Dec 13, 2016·Journal of Magnetic Resonance Imaging : JMRI·Gauraang BhatnagarStuart A Taylor
Apr 2, 2019·Journal of Gastroenterology and Hepatology·Shoichiro KawaiTetsuo Takehara
Jun 9, 2020·Inflammatory Bowel Diseases·Tomás RipollésBerta de Las Heras Paez
Oct 16, 2016·Journal of Clinical Gastroenterology·Charles N BernsteinReview Team:
Jun 7, 2020·Journal of Crohn's & Colitis·Fredrik SævikKim Nylund
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Jul 3, 2020·Journal of Crohn's & Colitis·Thomas M GoodsallRobert V Bryant
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Jan 24, 2020·Journal of the Canadian Association of Gastroenterology·Thomas M GoodsallRobert V Bryant

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