Ultrasound assessment of endothelial function in Chilean children and adults

Revista médica de Chile
Alfredo M GermainAda Cuevas

Abstract

Endothelial dysfunction is an important pathogenetic mechanism in the development of atherosclerosis. To evaluate endothelial function in Chilean children and adult subjects and to provide normal values of flow mediated dilatation (FMD) in the Chilean population. Flow mediated dilation of the brachial artery was measured by high resolution ultrasonography in healthy children (n=32) and adults (n=69) of both gender, in a group of 8 healthy women during 4 periods of pregnancy and late postpartum, and in 22 men and women with a history of stroke or coronary heart disease. FMD in boys and girls was 9.9 +/- 3.6 and 10.0 +/- 4.2% respectively (NS). The figures for young women and young men were 11.3 +/- 3.8 and 8.6 +/- 3.9, respectively (p=0.02); for postmenopausal women and older men, 5.5 +/- 6.6 and 7.6 +/- 6.7 respectively (NS). During normal pregnancy and postpartum there were no significant changes in FMD. Patients with cardiovascular disease had a FMD of 0.3 +/- 5.2%, (p <0.001, with other groups). The present study provides values of FMD in healthy Chilean subjects of different ages, and in patients with coronary heart disease.

Citations

Oct 13, 2015·Revista chilena de pediatría·Diego RodríguezLiliana Henao

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