Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Gabriela Aguilar-HernándezEfigenia Montalvo-González

Abstract

The soursop fruit or Annona muricata (A. muricata) fruit is recognized by its bioactive compounds and acetogenins (ACG) are among the most important. The effect of ACGs, with greater importance in health, is that they present anti-tumor activity; however, the methods of extraction of ACGs are very slow and with a high expenditure of solvents. To our knowledge, there is no report of an optimal method for the extraction of acetogenins from the Annonaceae family by ultrasound-assisted extraction (UAE); therefore, the aim was to find the best UEA conditions of acetogenins from A. muricata fruit (peel, pulp, seed, and columella) by using response surface methodology. The effect of amplitude (40%, 70%, and 100%), time (5, 10, and 15 min), and pulse-cycle (0.4, 0.7, and 1 s) of ultrasound at 24 kHz was evaluated on the total acetogenin content (TAC). Optimal extraction conditions of acetogenins (ACGs) with UEA were compared with the extraction of ACGs by maceration. The optimal UEA conditions in the A. muricata pulp and by-products were dependent on each raw material. The highest TAC was found in the seed (13.01 mg/g dry weight (DW)), followed by the peel (1.69 mg/g DW), the pulp (1.67 mg/g DW), and columella (1.52 mg/g DW). The exper...Continue Reading

References

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Jun 15, 2017·Genetics and Molecular Research : GMR·C F B SánchezL L Bhering
Sep 29, 2018·Food Science and Biotechnology·Luis Miguel Anaya-EsparzaEfigenia Montalvo-González
Jan 5, 2019·Journal of Plant Research·Claudia Azucena Durán-RuizAlma Rosa González-Esquinca
Mar 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriela Aguilar-HernándezEfigenia Montalvo González

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