Ultrasound biomicroscopy measurement of Schlemm's canal in pediatric patients with and without glaucoma

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Anika TandonRamesh S Ayyala

Abstract

To compare the diameter of Schlemm's canal in children with and without congenital glaucoma as measured in vivo by means of ultrasound biomicroscopy. In this prospective single-center study of pediatric subjects (<18 years of age) the diameter of Schlemm's canal in nonglaucomatous and glaucomatous eyes was compared. An 80 MHz iUltrasound probe (iScience Interventional Inc, Menlo Park, CA) placed near the limbus was used to identify and measure the canal's diameter with special attention to the anterior segment anatomy (especially in subjects with congenital glaucoma). A total of 20 subjects were included; mean age of subjects without glaucoma was 6.6 ± 6.65 years; of those with glaucoma, 9.4 ± 11.80 months. The mean canal diameter in nonglaucomatous eyes was 142 ± 33.2 μm (range, 90-196 μm); in glaucomatous eyes, 64.9 ± 10.90 μm (P = 0.007). Schlemm's canal could not be identified in 50% of patients with congenital glaucoma. There was a trend toward smaller canal diameter in subjects with no glaucoma <2 years old. Mean canal diameter in nonglaucomatous eyes was 103 ± 8 μm (range, 90-115 μm) in subjects <2 years of age and 161 ± 20 μm (range, 110-196 μm) in subjects >2 years of age (P = 0.0012). In our pediatric study cohort the...Continue Reading

References

Jun 1, 1985·Archives of Ophthalmology·R A Gordon, P B Donzis
Apr 27, 1999·The British Journal of Ophthalmology·H KobayashiT Kondo
Jan 19, 2010·Ophthalmology·Farhan A IrshadRamesh S Ayyala

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Citations

Sep 22, 2018·Acta Ophthalmologica·José Ignacio Fernández-VigoJosé Ángel Fernández-Vigo
Feb 19, 2020·Investigative Ophthalmology & Visual Science·Xian ZhangHao F Zhang
Oct 18, 2020·The British Journal of Ophthalmology·Rinky AgarwalRamanjit Sihota
Jan 8, 2021·Translational Vision Science & Technology·Christopher LeJanet L Alexander

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