Abstract
We aimed to study the validity of six published ultrasound criteria for risk stratification of thyroid nodules in the former severely iodine deficient population of Austria. Retrospective, single centre, observer blinded study design. All patients with a history of thyroidectomy due to nodules seen in the centre between 2004 and 2014 with preoperative in-house sonography and documented postoperative histology were analyzed (n = 195). A board of five experienced thyroidologists evaluated the images of 45 papillary carcinomas, 8 follicular carcinomas, and 142 benign nodules regarding the following criteria: mild hypoechogenicity, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, taller than wide shape, missing thin halo. All criteria but mild hypoechogenicity were significantly more frequent in thyroid cancer than in benign nodules. The number of positive criteria was significantly higher in cancer (2.79 ± 1.35) than in benign nodules (1.73 ± 1.18; p < 0.001). Thus, with a cut-off of two or more positive criteria, a sensitivity of 85% and a specificity of 45% were reached to predict malignancy in this sample of thyroid nodules. As expected, the findings were even more pronounced in papillary cance...Continue Reading
References
Aug 1, 1997·Thyroid : Official Journal of the American Thyroid Association·W BuchingerO Eber
Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Martin HeinischPeter Lind
Dec 19, 2002·Thyroid : Official Journal of the American Thyroid Association·P LindH Aigner
Jul 8, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M Weissel
Mar 19, 2004·Endocrine-related Cancer·C PasslerB Niederle
Mar 12, 2009·The Journal of Clinical Endocrinology and Metabolism·Eleonora HorvathMiguel Dominguez
Sep 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Ji-Young ParkSeong Hun Kim
Jul 21, 2011·Radiology·Jin Young KwakEun-Kyung Kim
Aug 9, 2011·Journal de radiologie·G RussM Bienvenu-Perrard
Feb 19, 2013·European Journal of Endocrinology·Gilles RussLaurence Leenhardt
Mar 1, 2013·European Thyroid Journal·Massimiliano AndrioliLuca Persani
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Dec 11, 2014·European Journal of Clinical Nutrition·H LindorferA Gessl
Dec 30, 2014·European Thyroid Journal·Gilles RussLaszlo Hegedüs
Sep 9, 2015·Radiology·Jung Hyun YoonJin Young Kwak
Oct 1, 2015·Journal of the American College of Radiology : JACR·Edward G GrantSharlene A Teefey
Oct 16, 2015·Thyroid : Official Journal of the American Thyroid Association·Bryan R HaugenLeonard Wartofsky
Dec 10, 2015·Thyroid Research·Arkadiusz Zygmunt, Andrzej Lewinski
Oct 6, 2016·Endocrinology and Metabolism·Ka Hee Yi
Nov 3, 2016·Radiology·Jung Hyun YoonJin Young Kwak
Apr 1, 2017·JAMA : the Journal of the American Medical Association·Hyeyeun LimCari M Kitahara
Jun 8, 2017·European Thyroid Journal·Carles ZafonDavid S Cooper
Jun 8, 2017·European Thyroid Journal·Roberto NegroEnrico Papini
Jun 8, 2017·European Thyroid Journal·Kaoru KobayashiAkira Miyauchi
Nov 24, 2017·European Thyroid Journal·Gilles RussLaurence Leenhardt
Citations
Apr 5, 2019·Oncology Letters·Zhixiang GaoJiping Yan
Jun 24, 2020·Wiener medizinische Wochenschrift·Christina Tugendsam, Amir Kurtaran
Mar 16, 2021·European Thyroid Journal·Roussanka D KovatchevaRadina S Ivanova