Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis

Osteoarthritis and Cartilage
L MancarellaR Meliconi

Abstract

To examine ultrasound (US) features of synovitis in hand osteoarthritis (OA) joints, and to evaluate their relationship with radiological damage severity and US-detected cartilage thickness. US examination was carried out on 14 joints of both hands of 25 patients with symptomatic hand OA (HOA) and 10 age- and sex-matched control subjects. US-detected features were: synovial hypertrophy, effusion, power Doppler signal (PDS), cartilage thickness. Conventional hand radiographs were scored utilizing the Kellgren-Lawrence and Kallman systems. HOA patients were divided into two subsets: non-erosive and erosive. Among the three groups of subjects studied, erosive OA showed the highest values of radiological scores and the highest prevalence of US-detected synovitis. Joints positive for US synovitis features (above all PDS) had higher radiological scores and lower cartilage thickness, while joints with X-ray detected central erosions [the hallmark of erosive HOA were more likely to present PDS positivity. US measured cartilage thickness inversely correlated with radiological damage scores. US-detected synovitis is present in about 10% of HOA finger joints and is associated with more severe radiological damage and reduced cartilage thic...Continue Reading

References

Jun 19, 2001·Annals of the Rheumatic Diseases·E QvistgaardH Bliddal
Sep 30, 2004·Best Practice & Research. Clinical Rheumatology·Leonardo PunziPaolo Sfriso
Mar 7, 2006·Current Rheumatology Reports·Sakeba N Issa, Leena Sharma
Aug 8, 2008·Annals of the Rheumatic Diseases·E NaredoI Sáenz-Navarro
Sep 2, 2008·Osteoarthritis and Cartilage·I MöllerA Iagnocco

❮ Previous
Next ❯

Citations

Oct 3, 2013·Zeitschrift für Rheumatologie·W HartungS Ohrndorf
Jul 16, 2011·Current Opinion in Rheumatology·Ali GuermaziDaichi Hayashi
Dec 12, 2012·Therapeutic Advances in Musculoskeletal Disease·Taeyoung KangRichard J Wakefield
Dec 21, 2013·Current Rheumatology Reports·Ida Kristin Haugen, Hilde Berner Hammer
Jan 26, 2013·Annals of the Rheumatic Diseases·Michael S SaltzherrJolanda J Luime
Apr 15, 2014·Reumatología clinica·Jacqueline UsónRoberto Miguélez
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Fredrick Joshua
Feb 8, 2011·Seminars in Arthritis and Rheumatism·Daichi HayashiAli Guermazi
Mar 26, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Santiago RutaUNKNOWN Pan-American League Against Rheumatisms (PANLAR) Ultrasound Study Group
Feb 16, 2011·Osteoarthritis and Cartilage·D HayashiD J Hunter
Apr 3, 2015·Annals of the Rheumatic Diseases·Alexander MathiessenIda K Haugen
Oct 4, 2016·Seminars in Arthritis and Rheumatism·David J GazeleyAnn K Rosenthal
May 30, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Babajide O OlubaniyiPriya S Suresh
Jan 17, 2014·The Journal of Rheumatology·Margreet KloppenburgDésirée M van der Heijde
Jan 20, 2018·Clinical Rheumatology·L Ventura-RíosC Hernández-Díaz
Sep 12, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marta FaveroRoberta Ramonda
Nov 5, 2021·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Esperanza NaredoDaniela Fodor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.