Ultrasound elastography in characterization of prostatic lesions: correlation with histopathological findings

The British Journal of Radiology
Doaa M EmaraMohamed M El Shafei

Abstract

Ultrasound elastography is increasingly used in the diagnosis of prostate cancer, however results are heterogeneous. We correlate in a large sample-size prospective study the accuracy of elastography, aiming to settle an accurate cut-off point for diagnosis and possibility of use as a screening tool. Prospective study that included 120 patients with mean age 59.5 ± 9.8 years, showing enlarged prostate by clinical examination with prostate-specific antigen >4 ng ml-1.The study was done using high frequency high resolution endorectal probe with real time tissue elastography.Grayscale ultrasound examination was done first with Doppler followed by elastography color-coded map and strain ratio measurement. Then, transrectal ultrasound-guided core biopsy was done from suspicious areas detected by elastography (totally or partly stiff by color-coded map or with relative increased strain ratio), besides standard six-quadrant core biopsy samples. There was statistically significant difference (p < 0.001) regarding strain ratio in benign and malignant lesions. Strain ratio showed significant proportionate correlation with prostate-specific antigen level and Gleason pathological score, while no significant correlation noted with the age o...Continue Reading

References

Sep 22, 2007·AJR. American Journal of Roentgenology·Iclal OcakPeter L Choyke
May 22, 2009·AJR. American Journal of Roentgenology·Gary J KelloffUNKNOWN Prostate Cancer Imaging Working Group
Nov 11, 2009·Nature Reviews. Urology·Nicolas B Delongchamps, Gabriel P Haas
Mar 31, 2010·Ultrasound in Medicine & Biology·Liang ZhaiKathryn R Nightingale
Aug 6, 2011·Ultrasound in Medicine & Biology·Atul KapoorBholla Singh Sidhu
Feb 24, 2012·Ultrasound Quarterly·Richard G BarrCarl R Schaub
Nov 3, 2012·The Lancet Oncology·Hashim Uddin AhmedMark Emberton
Apr 24, 2013·Diagnostic and Interventional Imaging·J-M CorreasO Hélénon
May 21, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sungmin WooSeung Hyup Kim
Jul 16, 2014·The Indian Journal of Radiology & Imaging·Sanjay Sharma
Dec 18, 2015·Journal of Ultrasonography·Markus PorschMaciej Pech
Mar 12, 2016·Biomedical Engineering and Computational Biology·Saradwata Sarkar, Sudipta Das
Mar 30, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sung Il HwangGheeyoung Choe
Aug 11, 2017·AJR. American Journal of Roentgenology·Sungmin WooSeung Hyup Kim

❮ Previous
Next ❯

Citations

Nov 10, 2021·The British Journal of Radiology·Adriano Basso DiasSangeet Ghai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.