Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
T HakozakiSeiji Arase

Abstract

Cutaneous hyperpigmentation occurs in multiple conditions. There is a strong need for the improvement of hyperpigmentation especially among Asian women. However, the effect of existing skin-lightening agents is not sufficient. One reason attributes to the limited capability of active agents to be delivered transepidermally. Ultrasound is one promising approach to enhance transepidermal transport. In this work, we investigate the effect of the use of high-frequency ultrasound together with coupling gel containing skin-lightening agents (ascorbyl glucoside and niacinamide) on facial hyperpigmentation in vivo in Japanese women. The effect of ultrasound on the absorption of skin-lightening agents into the stratum corneum was evaluated in a tape-stripping method on human forearms in vivo. The skin efficacy was assessed in a facial clinical trial involving 60 subjects with hyperpigmentation in a paired design. Subjects were assigned to two groups, each group using two treatments (one on each facial cheek): (1) skin-lightening gel with ultrasound vs. no treatment or (2) skin-lightening gel with ultrasound vs. skin-lightening gel treatment. Changes in facial hyperpigmentation were objectively quantified by computer analysis and visual ...Continue Reading

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Citations

Oct 30, 2009·International Journal of Molecular Sciences·Jody P EbanksRaymond E Boissy
Jan 31, 2012·Journal of the American Academy of Dermatology·Rebecca KleinermanEllen S Marmur
Nov 8, 2011·Colloids and Surfaces. B, Biointerfaces·Yang-Wei WangMing-Chien Yang
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Jul 31, 2007·Dermatologic Clinics·Mauro Picardo, Manuela Carrera
Sep 22, 2015·Therapeutic Delivery·Jessica A Scott, Ajay K Banga
Jul 25, 2009·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Hiroshi OhshimaMasatoshi Itoh
Nov 24, 2012·Journal of Cosmetic Dermatology·Nicholas P J Stamford
Oct 23, 2013·The British Journal of Dermatology·N A Vashi, R V Kundu
Sep 9, 2015·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S R ParkG S Choi
Nov 26, 2015·Ancient Science of Life·Khemchand SharmaChinky Goyal
May 24, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Peicong YuAnkur Purwar
Aug 21, 2020·International Journal of Dermatology·Kayla M BabbushAmor Khachemoune

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