Ultrasound findings predict progression to inflammatory arthritis in anti-CCP antibody-positive patients without clinical synovitis

Annals of the Rheumatic Diseases
Jackie L NamPaul Emery

Abstract

To determine whether ultrasound can identify anti-cyclic citrullinated peptide (anti-CCP) antibody-positive patients without clinical synovitis (CS) who progress to inflammatory arthritis (IA). In a prospective study, anti-CCP-positive patients without CS underwent ultrasound imaging of 32 joints (wrists, metacarpophalangeal joints, proximal interphalangeal joints and metatarsophalangeal joints (MTPs)) and were monitored for the development of IA. Associations between baseline ultrasound findings (grey scale (GS), power Doppler (PD) and erosions) and (1) progression to IA and (2) development of CS within an individual joint were measured. Consecutive anti-CCP-positive patients (n=136; mean age 51 years, 100 women) were followed up for median of 18.3 months (range 0.1-79.6). At baseline 96% had GS, 30% had PD and 21% had one or more erosions. IA developed in 57 patients (42%) after median of 8.6 months (range 0.1-52.4). Ultrasound abnormalities (GS ≥2, PD ≥1 or erosion ≥1) were found in 86% at baseline compared with 67% of non-progressors (χ(2)=6.3, p=0.012). Progression to IA was significantly higher in those with ultrasound findings in any joint (excluding MTPs for GS) (GS ≥2: 55% vs 24%, HR (95% CI) 2.3 (1.0 to 4.9), p=0.038;...Continue Reading

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Citations

Jan 15, 2017·Pediatric Rheumatology Online Journal·Natasha LeporeDaniela Simona Ardelean
Nov 10, 2017·Nature Reviews. Rheumatology·Hanna W van SteenbergenAnnette H M van der Helm-van Mil
Dec 24, 2017·Arthritis Research & Therapy·L OuboussadM H Buch
Oct 10, 2018·Annals of the Rheumatic Diseases·Kulveer MankiaPaul Emery
Mar 11, 2019·La Radiologia medica·Emilio FilippucciMarco Di Carlo
Jul 13, 2019·Cells·Bruno LucchinoManuela Di Franco
Oct 9, 2019·Nature Reviews. Rheumatology·Kulveer Mankia, Paul Emery
Jan 10, 2020·Annals of the Rheumatic Diseases·Annette van der Helm-van Mil, Robert B M Landewé
Dec 24, 2018·Annals of the Rheumatic Diseases·Kulveer MankiaPaul Emery
Jun 21, 2020·Current Rheumatology Reports·Andrea Di MatteoRichard J Wakefield
Dec 21, 2018·Arthritis Research & Therapy·Marian H van Beers-TasDirkjan van Schaardenburg
Dec 9, 2020·Lasers in Surgery and Medicine·Huan DengCecilia W P Li-Tsang
Mar 23, 2021·Autoimmunity Reviews·Nora PetrovskáMária Filková
Oct 14, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Claire DaienBernard Combe
May 6, 2021·Therapeutic Advances in Musculoskeletal Disease·Edoardo CipollettaEmilio Filippucci
Apr 24, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Gaël MouterdeMaria-Antonietta D'Agostino
May 14, 2021·Rheumatology·Laurette van BoheemenDirkjan van Schaardenburg
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Gurpreet Singh JutleyKarim Raza
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Jackie L Nam, Maria Antonietta D'Agostino
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Kulveer Mankia, Paul Emery
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Andrew P Cope

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