Ultrasound for the diagnosis of gout-the value of gout lesions as defined by the Outcome Measures in Rheumatology ultrasound group.

Rheumatology
Sara Nysom ChristiansenLene Terslev

Abstract

To evaluate ultrasound for diagnosing gout using consensus-based Outcome Measures in Rheumatology ultrasound definitions of gout lesions. Ultrasound was performed in patients with clinically suspected gout. Joints (28) and tendons (26) were binarily evaluated for the Outcome Measures in Rheumatology gout lesions-double contour (DC), tophus, aggregates and erosions. Ultrasound assessment was compared with two reference standards: (i) presence of MSU crystals in joint/tophus aspirate (primary outcome) and (ii) ACR/EULAR 2015 gout classification criteria (secondary outcome). Both reference standards were evaluated by rheumatologists blinded to ultrasound findings. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of each ultrasound lesion against both reference standards were determined. Eighty-two patients (70 men), mean age 62.4 (range 19-88) years, were included. Fifty-seven patients were MSU-positive whereas 25 patients were MSU-negative (no MSU crystals: 23; aspiration unsuccessful: 2). Of these 25 patients, three patients were classified as ACR/EULAR-positive (i.e. totally 60 ACR/EULAR-positive patients). All ultrasound lesions had high sensitivities for gout (0.77-0.95). DC and toph...Continue Reading

References

Apr 1, 1977·Arthritis and Rheumatism·S L WallaceT F Yü
Jun 19, 2001·Annals of the Rheumatic Diseases·M BackhausUNKNOWN Working Group for Musculoskeletal Ultrasound in the EULAR Standing Committee on International Clinical Studies including The
May 15, 2002·Annals of the Rheumatic Diseases·A SwanP Dieppe
Dec 23, 2006·Annals of the Rheumatic Diseases·Stephen A WrightAllister J Taggart
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Dec 7, 2007·Annals of the Rheumatic Diseases·S T Torp-Pedersen, L Terslev
Aug 7, 2012·Annals of the Rheumatic Diseases·Michael DohertyThomas Bardin
Sep 18, 2012·Annals of the Rheumatic Diseases·Esperanza NaredoUNKNOWN OMERACT Ultrasound Task Force*
Jan 17, 2014·Annals of the Rheumatic Diseases·Chang-Fu KuoMichael Doherty
Oct 30, 2014·Annals of the Rheumatic Diseases·William J TaylorTim L Jansen
Mar 26, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ole Slot, Lene Terslev
May 15, 2015·Rheumatology·Marwin GutierrezUNKNOWN OMERACT Ultrasound Gout Task Force group
Jul 8, 2015·Nature Reviews. Rheumatology·Chang-Fu KuoMichael Doherty
Oct 17, 2015·The Journal of Rheumatology·Lene TerslevUNKNOWN OMERACT US Gout Task Force
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp
Jun 16, 2017·The Journal of International Medical Research·Eleonora NorkuvieneAsta Baranauskaite
Feb 3, 2019·The Journal of Rheumatology·George A BruynUNKNOWN OMERACT Ultrasound Working Group
Jun 7, 2019·Annals of the Rheumatic Diseases·Pascal RichetteThomas Bardin

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Citations

May 22, 2021·Best Practice & Research. Clinical Rheumatology·Ashish J MathewLihi Eder

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