Nov 7, 2018

Ultrasound functional neuroimaging reveals propagation of task-related brain activity in behaving primates

BioRxiv : the Preprint Server for Biology
Alexandre DizeuxMickael Tanter


In recent decades, neuroimaging has played an invaluable role in improving the fundamental understanding of the brain. At the macro scale, neuroimaging modalities such as MRI, EEG, and MEG, exploit a wide field of view to explore the brain as a global network of interacting regions. However, this comes at the price of either limited spatiotemporal resolution or limited sensitivity. At the micro scale, electrophysiology is used to explore the dynamic aspects of neuronal activity with a very high temporal resolution. However, this modality requires a statistical averaging of several tens of single task responses. A large-scale neuroimaging modality of sufficient spatial and temporal resolution and sensitivity to study brain region activation dynamically would open new territories of possibility in neuroscience. We show that neurofunctional ultrasound imaging (fUS) is both able to assess brain activation during single cognitive tasks within superficial and deeper areas of the frontal cortex areas, and image the directional propagation of information within and between these regions. Equipped with an fUS device, two macaque rhesus monkeys were instructed before a stimulus appeared to rest (fixation) or to look towards (saccade) or ...Continue Reading

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Mentioned in this Paper

Diagnostic Radiology Modality
Supplementary Eye Field
Magnetic Resonance Imaging
Functional Neuroimaging
Spatial Distribution
Sample Fixation

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