Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study

Journal of Anesthesia
Ali AhiskaliogluErkan Cem Celik

Abstract

The postoperative analgesic effect of tizanidine has not yet been evaluated sufficiently. The role of bilateral superficial cervical plexus block (BSCPB) for postoperative analgesia after thyroidectomy remains questionable. We aimed to evaluate the analgesic effect of combined use of BSCPB and a single-dose oral tizanidine in patients undergoing elective thyroid surgery. Sixty patients undergoing thyroidectomy were randomized into 3 groups. The control group (Group C, n = 20) received BSCPB with 0.9% saline plus oral placebo. The superficial cervical group (Group SC, n = 20) received BSCPB with 0.25% bupivacaine plus oral placebo. The superficial cervical and tizanidine group (Group SC + T, n = 20) received BSCPB with 0.25% bupivacaine plus tizanidine 6 mg capsule. Surgical site pain scores, opioid consumption, rescue analgesia, posterior neck pain, headache, and opioid-related side effects were assessed for the first 24 h. Compared with Group C, rest and swallowing pain scores in Group SC and Group SC + T were statistically lower at all postoperative time points (p < 0.05). Fentanyl consumption was lower in Group SC and Group SC + T than in Group C at time periods 0-4 and 4-8 h (p < 0.05). Fentanyl consumption was lower in Gro...Continue Reading

Associated Clinical Trials

References

Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·M R Semenchuk, S Sherman
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·Dong Woo HanKi Jun Kim
Jul 26, 2006·Manual Therapy·César Fernández-de-Las-PeñasJuan A Pareja
Oct 27, 2014·Journal of Clinical Monitoring and Computing·Yavuz GürkanMine Solak
Mar 11, 2016·Advanced Biomedical Research·Reihanak TalakoubSayyed Morteza Heidari Tabaei Zavareh

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Citations

Mar 17, 2020·Dento Maxillo Facial Radiology·Theodosios SaranteasChristos Perisanidis
May 22, 2020·The Annals of Otology, Rhinology, and Laryngology·Brandon K NguyenPeter F Svider
Jul 15, 2021·American Journal of Surgery·Joana E OchoaJames X Wu
Aug 6, 2021·Journal of Perioperative Practice·Ryan MattisonMichael A Veronin

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