PMID: 15239260Jul 9, 2004Paper

Ultrasound-guided percutaneous boiling carboplatin injection (PBCI) for the treatment of small hepatocellular carcinoma: a preliminary study

Hepato-gastroenterology
Xiao-Yu YinXiao-Yan Xie

Abstract

To evaluate the therapeutic efficacy of ultrasound-guided percutaneous injection of boiling carboplatin (PBCI) for small hepatocellular carcinoma (HCC). PBCI was used to treat 34 HCC patients with 57 tumor nodules less than 3cm in diameter. Thirty-two of them (94.1%) were recurrent cases, including postoperative recurrence in 28, recurrence after percutaneous microwave coagulation therapy in 2 and recurrence after transcatheter arterial chemoembolization in 2. The remaining 2 had an initially treated HCC. Two sessions of PBCI were administered within 1 week for each tumor nodule. Its influences on liver function and blood cell count were monitored. Local recurrence rate, incidence of distant recurrence and survival rate were calculated by Kaplan-Meier method and their influencing factors were analyzed. Patients had a mean follow-up time of 12.7 +/- 5.4 months (from 3 to 22 months). Amount of boiling carboplatin solution (5mg/mL) injected per session ranged from 3mL to 35mL (10.9 +/- 6.9mL), and the total amount used in the two-session course ranged from 6mL to 65mL (21.8 +/- 13.4mL). Of 57 tumor nodules treated with two-session PBCI, technical success was achieved in 53 (93.0%). The cumulative local recurrence rate at 3, 6, 12,...Continue Reading

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