Ultrasound imaging demonstration of the improvement of non-ablative laser remodeling by concomitant daily topical application of 0.05% retinaldehyde

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
S MordonS Dahan

Abstract

Retinaldehyde has been proven to be effective in the reduction of facial wrinkles. It has also demonstrated its usefulness when used before and after laser skin resurfacing. A monocentric, comparative, randomized, double-blind study was performed to evaluate the efficacy of retinaldehyde versus excipient in combination with non-ablative laser remodeling treatment. A total of 16 female patients (mean age 45 years) were enrolled for neck line and forehead rhytid treatment. They were randomly assigned into two groups. The RAL group (eight patients) was treated with a non-ablative laser (1540 nm Er:glass, 10 J/cm2 per pulse, three pulses, 2 Hz repetition rate, 4 mm spot, +5 degrees C cooling) and daily topical application of 0.05% retinaldehyde immediately after the first laser treatment and up to 3 months after the fifth treatment. The CTRL group (eight patients) was treated under similar conditions, except with a daily application of excipient. The thickness of the skin (forehead and neck) was measured by ultrasound imaging before the first treatment, 1 month after the third treatment, 1 month after the fifth treatment and 3 months after the fifth treatment. An increase of dermal thickness was observed for all patients treated by...Continue Reading

References

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Citations

Dec 1, 2007·Clinical Interventions in Aging·Siddharth MukherjeeGünther Weindl
Jun 15, 2013·Otolaryngologic Clinics of North America·James M Hamilton, Edmund A Pribitkin
Sep 20, 2011·Seminars in Cutaneous Medicine and Surgery·Mary Lupo, Leah Jacob
Oct 19, 2005·Dermatologic Therapy·Christine C Dierickx, R Rox Anderson
Nov 24, 2006·Lasers in Medical Science·Mario A TrellesR Glen Calderhead
Jan 18, 2014·The Australasian Journal of Dermatology·Deshan F SebaratnamShawn Richards

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