Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series

The Lancet Child & Adolescent Health
Bruno SchaubDavid Baud

Abstract

Zika virus is a novel teratogenic agent associated with cerebral anomalies. Because of the challenges associated with assessment of antenatal diagnosis and prognosis in fetuses, screening for other congenital infections mostly relies on ultrasound. We aimed to assess whether a similar approach might be adequate for Zika virus congenital syndrome provided that early markers of infection and adequate timing for screening are established. For this case series we reviewed all pregnant women who had a laboratory-confirmed Zika virus infection in their first trimester or early second trimester and abnormal fetal ultrasound findings who were managed at the Pluridisciplinary Center for Prenatal Diagnosis of Martinique during the Zika virus epidemic (Jan 1, 2016, to Nov 10, 2016) in Martinique, a French Caribbean island. Ultrasound imaging was done with GE Healthcare Voluson E10 and E8 machines with abdominal and vaginal probes. We analysed 14 cases of pregnant women with confirmed Zika virus infection and fetal abnormalities of the brain, and 31 ultrasound imaging results. Between 16 and 20 weeks of gestation, four (33%) of 12 fetuses had an abnormal ultrasound examination. Anomalies were detected in nine (90%) of the ten fetuses from ...Continue Reading

Citations

Jul 10, 2019·Annual Review of Virology·Pradeep D UchilWalther Mothes
Oct 10, 2019·The New England Journal of Medicine·Didier MussoDavid Baud
Nov 29, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andrea Silveira de SouzaFernanda Tovar-Moll
Apr 19, 2018·Expert Review of Anti-infective Therapy·Francisco Javier Carod-Artal
Mar 15, 2018·The New England Journal of Medicine·Bruno HoenArnaud Fontanet
Sep 5, 2018·BMC Pregnancy and Childbirth·Manon VougaBruno Schaub
Apr 12, 2019·Frontiers in Cellular Neuroscience·Christian AlfanoLaurent Nguyen
Sep 18, 2020·Prenatal Diagnosis·Adriana MeloMelania M Ramos de Amorim
Dec 16, 2020·PloS One·Danielle A FreitasMayumi D Wakimoto
Jan 19, 2020·American Journal of Obstetrics and Gynecology·Marcela MercadoMartha L Ospina
Jun 13, 2021·BMJ Global Health·Luxi QiaoElizabeth B Brickley

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