Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats.

BMC Veterinary Research
Andréia S LessaRegina C S Goldenberg

Abstract

Domestic dogs and cats are very well known to develop chronic hepatic diseases, including hepatic lipidosis and cirrhosis. Ultrasonographic examination is extensively used to detect them. However, there are still few reports on the use of the ultrasound B-mode scan in correlation with histological findings to evaluate diffuse hepatic changes in rodents, which represent the most important animal group used in experimental models of liver diseases. The purpose of this study was to determine the reliability of ultrasound findings in the assessment of fatty liver disease and cirrhosis when compared to histological results in Wistar rats by following up a murine model of chronic hepatic disease. Forty Wistar rats (30 treated, 10 controls) were included. Liver injury was induced by dual exposure to CCl4 and ethanol for 4, 8 and 15 weeks. Liver echogenicity, its correlation to the right renal cortex echogenicity, measurement of portal vein diameter (PVD) and the presence of ascites were evaluated and compared to histological findings of hepatic steatosis and cirrhosis. Liver echogenicity correlated to hepatic steatosis when it was greater or equal to the right renal cortex echogenicity, with a sensitivity of 90%, specificity of 100%, ...Continue Reading

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Citations

Dec 29, 2013·American Journal of Veterinary Research·Tommaso BanzatoAlessandro Zotti
Jun 8, 2011·Ultrasound in Medicine & Biology·Itziar Fernández-DomínguezJuan Rodríguez-Cuesta
Jan 28, 2014·Ultrasound in Medicine & Biology·Hong WangYan Luo
Apr 20, 2017·Ultrasound Quarterly·Rustu TurkayMujdat Uysal

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Methods Mentioned

BETA
sedation
imaging technique
biopsies

Software Mentioned

US

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