Ultrasound in the diagnosis of calcium pyrophosphate dihydrate deposition disease. A systematic literature review and a meta-analysis

Osteoarthritis and Cartilage
G FilippouCarlo A Scirè

Abstract

Ultrasonography (US) demonstrated to be a promising tool for the diagnosis of calcium pyrophosphate dihydrate deposition disease (CPPD). The aim of this systematic literature review (SLR) was to collect the definitions for the US elementary lesions and to summarize the available data about US diagnostic accuracy in CPPD. We systematically reviewed all the studies that considered US as the index test for CPPD diagnosis without restrictions about the reference test or that provided definitions about US identification of CPPD. Sensitivity and specificity were calculated for each study and definitions were extrapolated. Subgroup analyses were planned by anatomical site included in the index text and different reference standards. Thirty-seven studies were included in this review. All the studies were eligible for the collection of US findings and all definitions were summarized. US description of elementary lesions appeared heterogeneous among the studies. Regarding US accuracy, 13 articles entered in the meta-analysis. Considering each joint structure, the sensitivity ranged between 0.77 (0.63-0.87) and 0.34 (0.16-0.58) while the specificity varies between 1.00 (0.89-1.00) and 0.92 (0.16-1.00). Considering the reference standards ...Continue Reading

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Citations

Oct 16, 2016·Rheumatic Diseases Clinics of North America·Patrick OmoumiAlexander So
Jan 3, 2019·Current Opinion in Rheumatology·Monica ZellJohn FitzGerald
Dec 21, 2019·Current Opinion in Rheumatology·Mariano AndrésEliseo Pascual
Apr 16, 2020·Current Rheumatology Reports·Georgios FilippouAnnamaria Iagnocco
Jan 22, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Viju MosesRobert Ike
Jul 28, 2019·Current Rheumatology Reports·Sara K Tedeschi
May 27, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Viju MosesRobert Ike

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