Ultrasound-induced cytolysis of cancer cells is enhanced in the presence of micron-sized alumina particles

Ultrasonics Sonochemistry
N MiyoshiJoe Z Sostaric

Abstract

Micron-sized alumina particles have been shown to enhance sonochemical free radical formation in aqueous solutions and simultaneously increase the solution temperature and acoustic (white) noise, effects attributable to enhanced inertial cavitation [T. Tuziuti, J. Phys. Chem. A 109 (2005) 4869-4872]. In the current study, the same ultrasound exposure system was applied to in vitro cancer cells as a model system to determine the effect of alumina particles on the long-term survival of cells and on the major pathways of cell death, i.e., either apoptosis or necrosis. Following 6h of incubation after ultrasound treatment, it was found that the cells died mainly through necrosis, irrespective of whether the exposure was conducted in the presence of alumina particles or not. Alumina particles were non-toxic to cells alone, but were found to decrease the long-term survivability of cells that survived the initial exposure. This effect depended on the size and concentration of particles. These results correlated well with the effect of alumina particles on the sonochemical oxidation of KI under the same exposure conditions. Spin-trapping with 5,5-dimethyl-pyroline N-oxide (DMPO) and electron spin resonance spectroscopy indicated that t...Continue Reading

References

Jan 1, 1996·Ultrasound in Medicine & Biology·M W MillerA A Brayman
May 21, 1999·The Journal of the Acoustical Society of America·M WardJ F Chiu
Jun 17, 2000·Ultrasound in Medicine & Biology·D L Miller, J Quddus
Nov 1, 2001·Journal of the American Chemical Society·J Z Sostaric, P Riesz
May 3, 2003·Ultrasonics Sonochemistry·Shinobu KodaHideto Mitome
Oct 30, 2004·The Journal of Gene Medicine·Hiromi KoikeRyuichi Morishita
Nov 22, 2005·Free Radical Biology & Medicine·Joe Z SostaricJames B Mitchell
Jul 13, 2006·The Journal of Physical Chemistry. a·Toru TuziutiNorio Miyoshi

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Citations

Sep 6, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Xianyong YuShizhong Zhu
Jul 1, 2015·Journal of Therapeutic Ultrasound·Mahboobeh Alamolhoda, Manijhe Mokhtari-Dizaji
Oct 28, 2009·Anesthesiology·Philip C Cory
May 13, 2008·The Journal of Physical Chemistry. a·Toru TuziutiYasuo Iida

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