Ultrasound-induced encapsulated microbubble phenomena

Ultrasound in Medicine & Biology
Michiel PostemaN de Jong

Abstract

When encapsulated microbubbles are subjected to high-amplitude ultrasound, the following phenomena have been reported: oscillation, translation, coalescence, fragmentation, sonic cracking and jetting. In this paper, we explain these phenomena, based on theories that were validated for relatively big, free (not encapsulated) gas bubbles. These theories are compared with high-speed optical observations of insonified contrast agent microbubbles. Furthermore, the potential clinical applications of the bubble-ultrasound interaction are explored. We conclude that most of the results obtained are consistent with free gas bubble theory. Similar to cavitation theory, the number of fragments after bubble fission is in agreement with the dominant spherical harmonic oscillation mode. Remarkable are our observations of jetting through contrast agent microbubbles. The pressure at the tip of a jet is high enough to penetrate any human cell. Hence, liquid jets may act as remote-controlled microsyringes, delivering a drug to a region-of-interest. Encapsulated microbubbles have (potential) clinical applications in both diagnostics and therapeutics.

References

Jan 1, 1993·Ultrasound in Medicine & Biology·B A Schrope, V L Newhouse
Jan 1, 1993·Ultrasonics·N de Jong, L Hoff
Jul 4, 1998·Ultrasonics·P J FrinkingS Keating
Jul 4, 1998·Ultrasound in Medicine & Biology·P J Frinking, N de Jong
Aug 8, 1998·Ultrasound in Medicine & Biology·T Kodama, K Takayama
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C RotschM Radmacher
May 5, 1999·Lancet·K TachibanaK Tamura
Oct 26, 1999·The Journal of the Acoustical Society of America·P M ShankarV L Newhouse
Nov 27, 1999·Ultrasound in Medicine & Biology·P DaytonK Ferrara
Apr 25, 2000·Ultrasound in Medicine & Biology·N de JongF Mastik
May 5, 2000·Ultrasound in Medicine & Biology·M W Miller
Jun 1, 2000·Ultrasonics·N de JongF J Ten Cate
Jun 6, 2000·Advanced Drug Delivery Reviews·A L Klibanov
Sep 21, 2000·Ultrasound in Medicine & Biology·W T ShiB B Goldberg
Feb 27, 2001·Biophysical Journal·P A DaytonK W Ferrara
Apr 1, 1997·Ultrasonics Sonochemistry·W Lauterborn, C D Ohl
May 23, 2001·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·J E ChomasK W Ferrara
May 29, 2001·Journal of Biomedical Optics·J E ChomasK Ferrara
May 31, 2001·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·P J FrinkingN de Jong
Oct 13, 2001·Ultrasound in Medicine & Biology·P TortoliY Takeuchi
Mar 7, 2002·Ultrasound in Medicine & Biology·Ayache BouakazNico de Jong
Mar 13, 2002·Circulation·Yoshiaki TaniyamaRyuichi Morishita
Apr 27, 2002·European Journal of Radiology·Evan C UngerRachel Quigley
Aug 6, 2002·Ultrasonics·Nico de JongFolkert J Ten Cate
Aug 6, 2002·Ultrasonics·Ayache BouakazNico de Jong
Oct 26, 2002·The Journal of the Acoustical Society of America·Anil J Reddy, Andrew J Szeri
May 9, 2003·Nature·Philippe Marmottant, Sascha Hilgenfeldt
May 17, 2003·Ultrasound in Medicine & Biology·Eleanor Stride, Nader Saffari
Jun 6, 2003·Physical Review Letters·C D Ohl, R Ikink
Mar 30, 2004·Ultrasonics·Michiel PostemaNico de Jong
Dec 8, 2004·Ultrasound in Medicine & Biology·Michiel PostemaNico de Jong
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·K E MorganK W Ferrara

❮ Previous
Next ❯

Citations

Jul 5, 2013·The Review of Scientific Instruments·Xucai ChenFlordeliza S Villanueva
Jan 1, 2014·Journal of Medical Ultrasonics·Noboru SasakiMitsuyoshi Takiguchi
Nov 26, 2013·Advanced Drug Delivery Reviews·I LentackerC T W Moonen
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Aug 4, 2007·The Journal of the Acoustical Society of America·Charles F CaskeyKatherine W Ferrara
Jul 15, 2009·Medical & Biological Engineering & Computing·Gail ter Haar
Sep 26, 2014·BioMed Research International·Ai-Ho LiaoChih-Hung Wang
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Neveen A HosnyMarina K Kuimova
Oct 5, 2006·Physics in Medicine and Biology·Shengping Qin, Katherine W Ferrara
Jul 9, 2008·Journal of Proteome Research·Daniel López-FerrerRichard D Smith
Jan 26, 2010·Nanotechnology·E Y Lukianova-HlebD O Lapotko
May 11, 2010·Nanotechnology·E Y Lukianova-HlebD O Lapotko
Oct 21, 2010·Molecular Pharmaceutics·Stephanie J GraingerMohamed E H El-Sayed
May 13, 2009·Medical & Biological Engineering & Computing·Eleanor Stride, Mohan Edirisinghe
Dec 19, 2012·The Journal of Antimicrobial Chemotherapy·Ying DongJialin Yu
Mar 13, 2014·Talanta·J E AraújoJ L Capelo
Mar 8, 2008·Basic Research in Cardiology·Georg Schmitz
Apr 6, 2005·Der Radiologe·C Kollmann, M Putzer
Oct 27, 2004·Der Urologe. Ausg. A·H HeynemannP Fornara
Jun 7, 2005·Expert Review of Molecular Diagnostics·Peter Heppner, Jonathan R Lindner
Apr 5, 2013·Expert Opinion on Drug Delivery·Ying-Zheng ZhaoJun Cai
Nov 4, 2008·Journal of Pharmaceutical Sciences·Steliyan TinkovConrad Coester
Dec 18, 2015·Ultrasound in Medicine & Biology·Brandon HelfieldFlordeliza S Villanueva
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ine De CockIne Lentacker
Dec 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Galina ShapiroDan Gazit
Jul 7, 2012·Ultrasound in Medicine & Biology·Jonathan E LeemanJohn J Pacella
Oct 4, 2011·Ultrasound in Medicine & Biology·Costas D ArvanitisConstantin C Coussios
Nov 1, 2011·Ultrasound in Medicine & Biology·Hong ChenThomas J Matula
May 10, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Linsey C PhillipsJohn A Hossack
Mar 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bart GeersStefaan C De Smedt
Aug 31, 2010·Ultrasound in Medicine & Biology·D H ThomasV Sboros
Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Z FanC X Deng
May 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ratnesh JainVandana Patravale
Apr 11, 2009·Medical Engineering & Physics·Emil-Alexandru Brujan
Mar 11, 2009·European Journal of Radiology·Marcel R BöhmerOliver C Steinbach
Dec 27, 2008·Ultrasound in Medicine & Biology·Thomas Barrack, Eleanor Stride
Nov 18, 2008·Ultrasound in Medicine & Biology·R E KumonC X Deng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Michiel PostemaN de Jong
Ultrasound in Medicine & Biology
Michiel PostemaN de Jong
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Paul A DaytonKatherine W Ferrara
© 2022 Meta ULC. All rights reserved