Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study.

Neonatology
Pramod PharandeAtul Malhotra

Abstract

Fetal growth restriction (FGR) is associated with neonatal and long-term neuro-morbidity. Preferential redistribution of blood flow to the brain is a common antenatal adaptation in FGR. The impact of this "brain sparing," which may signify severity of FGR, on the growth of brain structures has not been studied. To compare corpus callosum (CC), cerebellar, and ventricular measurements of FGR neonates with evidence of fetal blood flow redistribution with those of gestation-matched appropriately grown (AGA) neonates. This was a pilot, prospective observational study conducted at a tertiary level neonatal unit in Melbourne, Australia. Cranial ultrasound was done between days 1 and 3 of life in FGR and AGA neonates. Cranial ultrasound on 20 FGR, gestation (mean ± SD) 31.4 ± 3.1 weeks, weight 1,205 ± 463 g, and 20 AGA neonates, 31.1 ± 3.0 weeks, 1,668 ± 490 g, was performed. CC length was significantly decreased in FGR neonates as compared to AGA neonates (35.28 ± 3.47 vs. 38.83 ± 4.05 mm, p = 0.0002). CC was significantly thinner at genu (3.36 ± 0.66 vs. 4.04 ± 0.83 mm, p = 0.007), body (1.97 ± 0.36 vs. 2.27 ± 0.39 mm, p = 0.02), and splenium (4.07 ± 0.76 vs. 4.72 ± 0.75 mm, p = 0.003) in FGR vs. AGA neonates. CC-fastigium length wa...Continue Reading

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Citations

Aug 8, 2021·Journal of Clinical Ultrasound : JCU·Betül YakiştiranAykan Yücel
Dec 9, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Joshua I RosenbloomShay Porat

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