Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts

Cancer Letters
Li LiuRonald X Xu

Abstract

We have synthesized multifunctional oxygen and paclitaxel loaded microbubbles (OPLMBs) for ultrasound mediated delivery of combination therapy in an ovarian cancer xenograft model. In comparison with other therapeutic options, intravenous injection of OPLMBs followed by ultrasound mediation yielded a superior therapeutic outcome. Immunohistochemical analyses of the dissected tumor tissue confirmed the increased tumor apoptosis and the reduced VEGF expression after treatment. Western Blot tests further confirmed the decreased expressions of HIF-1α and P-gp. Our experiment suggests that ultrasound mediation of OPLMBs may provide a promising drug delivery strategy for the combination treatment of ovarian cancer.

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Feb 11, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junping ZhongDa Xing
Oct 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ashim K MitraDhananjay Pal
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May 1, 2021·International Journal of Molecular Sciences·Vrinda GoteDhananjay Pal
Aug 29, 2021·Pharmaceutics·Kristin Entzian, Achim Aigner
Sep 28, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Buyun GuoRonald X Xu

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