Ultrasound neuromodulation: mechanisms and the potential of multimodal stimulation for neuronal function assessment.

Frontiers of Physics
Hermes A S KamimuraElisa E Konofagou

Abstract

Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of animal scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell type specificity typical of other, more invasive techniques e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multimodal stimulation approach involving electric...Continue Reading

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Citations

Jan 19, 2021·Ultrasound in Medicine & Biology·Christian AurupElisa E Konofagou
Nov 13, 2021·Chemical Reviews·Athanasios G AthanassiadisPeer Fischer
Jan 28, 2022·Bioelectronic Medicine·Marta SaccherRonald Dekker

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