Ultrasound Reversible Response Nanocarrier Based on Sodium Alginate Modified Mesoporous Silica Nanoparticles

Frontiers in Chemistry
Xiaochong LiHesheng Xia

Abstract

Mesoporous silica nanoparticles (MSN) covered by polymer coatings, cross-linked by weak coordination bonds were expected to present a reversible responsiveness under on-off ultrasound stimuli. Herein, we prepared a sodium alginate (SA) modified MSN with carboxyl-calcium (COO--Ca2+) coordination bonds in the modified layer, which could block the mesopores of MSN and effectively prevent the cargo from pre-releasing before stimulation. The coordination bonds would be destroyed under the stimulation of low intensity ultrasound (20 kHz) or high intensity focused ultrasound (HIFU, 1.1 MHz), leading to a rapid and significant cargo release, and then they could be reformed when ultrasound was turned off, resulting in an instant cargo release stopping. The reversible cleavage and reformation of this coordination bonds under on-off ultrasound stimulus were confirmed by the gel-sol transition behaviors of the SA-CaCl2 gels. An excellent real-time control of rhodamine B (RhB) release performance was obtained under the ultrasound stimuli. Obviously, the cargo release ratio could reach to nearly 40% when HIFU (80 W) was turned on for 5 min, and remained basically constant when ultrasound was turned off, which would finally reach to nearly 10...Continue Reading

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Citations

May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Apr 17, 2021·ACS Pharmacology & Translational Science·Nahid S AwadGhaleb A Husseini
Apr 16, 2021·Journal of the American Chemical Society·Fang-Chu LinJeffrey I Zink
May 1, 2021·Pharmaceutics·Alex N FrickensteinLacey R McNally
Aug 29, 2021·Pharmaceutics·Kristin Entzian, Achim Aigner
Sep 4, 2021·Beilstein Journal of Nanotechnology·Sepand Tehrani FatehAmin Shiralizadeh Dezfuli

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Methods Mentioned

BETA
scanning electron microscopy
X-ray

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