Ultrasound screening: Status of markers and efficacy of screening for structural abnormalities

Seminars in Perinatology
Rashmi Rao, L Platt

Abstract

Aneuploidy is a major cause of perinatal morbidity and mortality and can have a significant impact on expecting parents and their families. With early screening and diagnosis it is important to be able to educate parents regarding the potential impact of the diagnosis. This knowledge allows parents the opportunity to consider management options early in the pregnancy, permitting more time to mentally and emotionally prepare both for the course of the pregnancy, and after the birth of the child should the pregnancy continue. Prenatal screening provides pregnant women a non-invasive risk assessment for the most common aneuploidies. Those who are considered "high-risk" then have the option for additional diagnostic (invasive) testing. Prior to the 1980s, prenatal screening consisted of risk assessment through maternal age; however, with the advent of maternal serum biochemical analysis and ultrasound, the field of prenatal screening developed significantly. As biochemical and sonographic advances continued into the 1990s, the emphasis shifted to risk assessment in the first trimester, with the combination of maternal serum analytes and sonographic evaluation of the nuchal translucency.(1) Within the last decade, the introduction o...Continue Reading

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Citations

May 16, 2018·Journal of Midwifery & Women's Health·Rebekah Kaplan, Sharon Adams
Mar 22, 2020·Molecular Genetics & Genomic Medicine·Wei LiZhiyu Peng
Aug 28, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
May 12, 2019·BMC Pregnancy and Childbirth·Peri AbdullahHala Tamim
Aug 8, 2020·Archives of Gynecology and Obstetrics·Keren Tzadikevitch GeffenRivka Sukenik Halevy
Nov 1, 2020·American Journal of Obstetrics and Gynecology·Yimei LiaoShengli Li
Apr 30, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Filomena G SileoEmma Bertucci

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