Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Ricardo SerôdioAna L Oliveira

Abstract

In this study, silk fibroin (SF)/poly(ethylene oxide) (PEO) membranes were designed and fabricated by combining ultrasound sonication prior to electrospinning (0 to 20 min) as a strategy to physically control the rheological properties of solutions (10 to 30% w/v PEO) and to improve the spinnability of the system. PEO has proved to be essential as a co-spinning agent to assure good membrane reproducibility and enough flexibility for clinical manipulation. The rheological tests indicated that sonication greatly increased the viscosity of SF/PEO solutions and further enhanced the quality of the produced electrospun fibers with consequent improved mechanical properties in dry and wet conditions. By tuning the viscosity of the solutions using a simple sonication step prior to electrospinning, it was possible to induce water stability in the as-electrospun matrix, as demonstrated by infra-red spectroscopy. This reduced complexity in the process since it was not necessary to concentrate silk prior to electrospinning while avoiding the use of toxic solvents to perform a post-processing stabilization treatment which usually causes dimensional changes to the SF materials. Sonication pre-treatment allowed for minimizing the amount of syn...Continue Reading

Citations

May 1, 2021·Journal of Functional Biomaterials·Sebastian Wilk, Aleksandra Benko
Jun 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shengzhi ZouHuili Shao
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zhinan MaoSujun Wu
Jan 7, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yushui HeHong Tan

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