Ultrasound surveillance for radiation-induced thyroid carcinoma in adult survivors of childhood cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Enrico BrignardelloNicola Palestini

Abstract

The optimal surveillance strategy to screen for thyroid carcinoma childhood cancer survivors (CCS) at increased risk is still debated. In our clinical practice, beside neck palpation we routinely perform thyroid ultrasound (US). Here we describe the results obtained using this approach. We considered all CCS referred to our long term clinic from November 2001 to September 2014. One hundred and ninety-seven patients who had received radiation therapy involving the thyroid gland underwent US surveillance. Thyroid US started 5 years after radiotherapy and repeated every 3 years, if negative. Among 197 CCS previously irradiated to the thyroid gland, 74 patients (37.5%) developed thyroid nodules, and fine-needle aspiration was performed in 35. In 11 patients the cytological examination was suspicious or diagnostic for malignancy (TIR 4/5), whereas a follicular lesion was diagnosed in nine. Patients with TIR 4/5 cytology were operated and in all cases thyroid cancer diagnosis was confirmed. The nine patients with TIR 3 cytology also underwent surgery and a carcinoma was diagnosed in three of them. Prevalence of thyroid cancer was 7.1%. Tumour size ranged between 4 and 25 mm, but six (43%) were classified T3 because of extra-thyroidal...Continue Reading

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Citations

May 28, 2016·Endocrine-related Cancer·Mark WijnenSebastian Neggers
Nov 27, 2018·Endocrine Reviews·Judith GebauerGeorg Brabant
Feb 6, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Yu FuruiYozo Nakazawa
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Oct 21, 2017·Endocrinología, Diabetes Y Nutrición·Paula Casano Sancho
Dec 13, 2018·Hormone Research in Pædiatrics·Steven G Waguespack

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