PMID: 107501Apr 1, 1979

Ultrastructural alterations in experimental lingual leukoplakia and carcinoma

Oral Surgery, Oral Medicine, and Oral Pathology
M P MarefatG Shklar


Epidermoid carcinomas, preceded by dysplastic leukoplakic lesions, were produced on the right lateral borders of the tongues of Syrian hamsters by the application, three times per week, of DMBA in acetone after the area had been scratched with a root canal broach. Animals were killed at 12 to 13 weeks and 15 to 16 weeks. Electron microscopic studies of both the dysplastic leukoplakic lesions and the well-differentiated epidermoid carcinomas revealed clumping of tonofilaments and widening of intercellular spaces, in addition to the cellular pleomorphism, altered nuclear-cytoplasmic ratio, and prominent nucleoli observed with the light microscope. In the carcinomas, there were variations in the morphology of mitochondria, with tubular forms in evidence. The basal lamina in the carcinomas was discontinuous. Pseudopodia arising from basal cells were seen in areas of basal lamina discontinuity.


Nov 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·S Y Chen, R D Harwick
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Feb 1, 1974·The Journal of Cell Biology·H L Malech, T L Lentz
Jan 1, 1966·Journal of Periodontology·S al-Ani, G Shklar
Oct 1, 1969·Journal of Periodontology·A Z Mesrobian, G Shklar
Apr 1, 1954·Journal of Dental Research·J J SALLEY
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Jan 1, 1961·Journal of Dental Research·A L MORRIS
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Nov 1, 1963·Oral Surgery, Oral Medicine, and Oral Pathology·S SILBERMAN, G Shklar
Jun 1, 1962·The Journal of the American Dental Association·G RENSTRUPI GLICKMAN


Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·S V Kandarkar, S S Sawant
Apr 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G S McKayD M Chisholm
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Related Concepts

Squamous Cell Carcinoma
Neoplasms, Experimental
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