PMID: 107501Apr 1, 1979

Ultrastructural alterations in experimental lingual leukoplakia and carcinoma

Oral Surgery, Oral Medicine, and Oral Pathology
M P MarefatG Shklar

Abstract

Epidermoid carcinomas, preceded by dysplastic leukoplakic lesions, were produced on the right lateral borders of the tongues of Syrian hamsters by the application, three times per week, of DMBA in acetone after the area had been scratched with a root canal broach. Animals were killed at 12 to 13 weeks and 15 to 16 weeks. Electron microscopic studies of both the dysplastic leukoplakic lesions and the well-differentiated epidermoid carcinomas revealed clumping of tonofilaments and widening of intercellular spaces, in addition to the cellular pleomorphism, altered nuclear-cytoplasmic ratio, and prominent nucleoli observed with the light microscope. In the carcinomas, there were variations in the morphology of mitochondria, with tubular forms in evidence. The basal lamina in the carcinomas was discontinuous. Pseudopodia arising from basal cells were seen in areas of basal lamina discontinuity.

References

Nov 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·S Y Chen, R D Harwick
Oct 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·P Marefat, G Shklar
Feb 1, 1974·The Journal of Cell Biology·H L Malech, T L Lentz
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Citations

Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·S V Kandarkar, S S Sawant
Apr 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G S McKayD M Chisholm
Nov 1, 1988·Pathology, Research and Practice·K P Dingemans
Jul 1, 1989·Oral Surgery, Oral Medicine, and Oral Pathology·H MaedaE Sato
Jan 1, 1986·Journal of Oral Pathology·H Maeda, Y Kameyama
Jun 1, 1981·Journal of Oral Pathology·J W Eveson
Apr 1, 1991·International Journal of Oral and Maxillofacial Surgery·J W FergusonA C Smillie
Apr 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·G ShklarK D Wallace
Dec 1, 1981·The Journal of Dermatologic Surgery and Oncology·G Shklar

Related Concepts

Benz(a)Anthracenes
Squamous Cell Carcinoma
Cricetus
Mesocricetus
Neoplasms, Experimental
Malignant Neoplasm of Tongue
9,10-Dimethyl-1,2-benzanthracene

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